Mechanism of radio-sensitizing effect caused by angiogenesis inhibitor
| Project/Area Number |
21591726
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | The University of Tokushima |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KURITA Nobuhiro 徳島大学, 病院, 特任教授 (30335814)
IWATA Takashi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (00380022)
YOSHIKAWA Kozo 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (80448331)
武田 美雄 徳島大学, 大学院・ソシオ・アーツアンド・サイエンス研究部, 教授 (70025716)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 癌 / 放射線 / 血管新生 / 放射線増感剤 / 低酸素 / HIF-1 / Oridonin / TPI(Thymidine phosphorylase inhibitor) / TPI (Thymidine phosphorylase inhibitor) |
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| Research Abstract |
Combination of TPI and RT synergistically inhibited the cell viability in a time-and dose-dependent manner. The combination of TPI and RT reduced the tumor growth compared with RT alone. The mRNA levels of VEGF, TGF-b and Rad51 and the protein expressions of VEGF and CD34 were significantly lower in the combination than the others. The combination markedly increased the TUNEL positive cells, suggesting that TPI augments the cancer cell death through inhibition of angiogenesis and DNA repair system in the radiotherapy. Oridonin suppressed growth of HCT-15 and HT-29 cells through induction of apoptosis and autophagy. However, combined with RT and Oridonin augmented growth suppression through induction of apoptosis. In orthotpoic model, combination of RT and Oridonin showed significant reductions in tumor volume.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Platelet-derived endothelial cell growth factor/ thymidine phosphorylase inhibitor augments radiotherapeutic efficacy in experimental colorectal cancer.2012
Author(s)
Miyatani T, Kurita N, Utsunomiya T, Iwata T, Nishioka M, Yoshikawa K, Higashijima J, Kashihara H, Takasu C, Fukushima M, Shimada M.
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Journal Title
Cancer Lett
Volume: 318(2)
Issue: 2
Pages: 199-205
DOI
Related Report
Peer Reviewed
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[Journal Article] Preoperative Radiotherapy Combined with S-1 for Advanced Lower Rectal Cancer : Phase I Trial2011
Author(s)
Morimoto S, Shimada M, Kurita N, Sato H, Iwata T, Nishioka M, Yoshikawa K, Miyatani T, Kashihara H, Takasu C, Ikushima H.
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Journal Title
Hepatogastroenterology
Volume: 59(117)
DOI
Related Report
Peer Reviewed
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[Journal Article] The Kampo medicine, Goshajinkigan, prevents neuropathy in patients treated by FOLFOX regimen2011
Author(s)
Nishioka M, Shimada M, Kurita N, Iwata T, Morimoto S, Yoshikawa K, Higashijima J, Miyatani T, Kono T.
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Journal Title
Int J Clin Oncol
Volume: 16(4)
Pages: 322-7
NAID
Related Report
Peer Reviewed
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[Presentation] Utsunomiya T. Rediosensitizing effects of oridonin for human colon cancer.(オリドニンの放射線増感作用に関する検討.)2010
Author(s)
Mikami C, Shimada M, Kurita N, Iwata T, Nishioka M, Morimoto S, Yoshikawa K, Miyatani T, Komatsu M, Kashihara H,
Organizer
第69回日本癌学術総会
Place of Presentation
大阪国際会議場大阪市
Year and Date
2010-09-23
Related Report
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[Presentation] オリドニンの放射線増感作用に関する検討2010
Author(s)
小松正人, 島田光生, 西岡将規, 栗田信浩, 岩田貴, 森本慎也, 吉川幸造, 東島潤, 宮谷知彦, 中尾寿宏, 柏原秀也, 宇都宮徹
Organizer
第110回日本外科学会定期学術集会
Place of Presentation
名古屋国際会議場名古屋市
Year and Date
2010-04-08
Related Report
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