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The clinical significance of ING2 expression in colorectal cancr

Research Project

Project/Area Number 21591728
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionFukushima Medical University (2013)
Saitama Medical University (2009-2012)

Principal Investigator

KUMAMOTO Kensuke  福島県立医科大学, 医学部, 講師 (60457778)

Co-Investigator(Kenkyū-buntansha) TAKENOSHITA Seiichi  福島県立医科大学, 医学部, 教授 (10167489)
Project Period (FY) 2009-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2013: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2012: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2011: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords大腸癌 / ING2 / P53 / p53
Research Abstract

The biological significance of the ING2 gene expression in colon cancer will be clarified by in vitro experiments using colon cancer cell lines. The aim of this study is to develop the molecules target treatment in clinical practice. In immunohistochemical analysis of ING2 with 130 colorectal cancer, the strong staining was observed in 78 (60%) cases. Overexpression of ING2 induced MMP13 mRNA expression using a colon cancer cell line, HCT116, into which adenoviral ING2 expression vector was transfected, in cDNA microarray analysis. ING2 overexpressed cells acquired the ability of invasion, leading to suggest that enhanced ING2 expression in colorectal cancer might be associated with cellular invasion and metastasis. Weak expression of ING2 was associated with the effect of preoperative chemoradiotherapy for advanced lower rectal cancer. Therefore ING2 could be the useful marker for the effect of preoperative chemoradiotherapy for advanced lower rectal cancer.

Report

(6 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (14 results)

All 2013 2011 2010 2009

All Journal Article (10 results) (of which Peer Reviewed: 6 results) Presentation (4 results)

  • [Journal Article] Polymorphisms of GSTP1, ERCC2 and TS-3'UTR are associated with the clinical outcome of mFOLFOX6 in colorectal cancer patients.2013

    • Author(s)
      Kumamoto K, Ishibashi K, Okada N, Tajima Y, Kuwabara K, Kumagai Y, Baba H, Haga N, Ishida H.
    • Journal Title

      Oncology Letters

      Volume: 6 Pages: 648-654

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 大腸癌-最新の研究動向- VIII.大腸癌の治療戦略化学療法FOLFOX療法の治療効果予測因子の探索(TS、ERCC1など)2011

    • Author(s)
      隈元謙介、石橋敬一郎、石田秀行
    • Journal Title

      日本臨牀

      Volume: 69巻 Pages: 494-499

    • Related Report
      2013 Final Research Report
  • [Journal Article] 特集消化器癌における分子標的治療4.大腸癌における分子標的治療a)切除不能大腸癌における分子標的治療2011

    • Author(s)
      隈元謙介、石橋敬一郎、石田秀行
    • Journal Title

      外科

      Volume: 73巻 Pages: 243-251

    • Related Report
      2013 Final Research Report
  • [Journal Article] Targeted disruption of Ing2 results in defective spermatogenesis and development of soft-tissue sarcomas2010

    • Author(s)
      Saito M、Kumamoto K、Robles AI、Horikawa I、Furusato B、Okamura S、Goto A、Yamashita T、Nagashima M、Lee TL、Baxendale VJ、Rennert OM、Takenoshita S、Yokota J、Sesterhenn IA、Trivers GE、Hussain SP、Harris CC
    • Journal Title

      PLoS One

      Volume: 5巻

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Targeted disruption of Ing2 results in defective spermatogenesis and development of soft-tissue sarcomas.2010

    • Author(s)
      Saito M, Kumamoto K, et al.
    • Journal Title

      PLoS One

      Volume: 5 Pages: 15541-15541

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ING22009

    • Author(s)
      隈元謙介
    • Journal Title

      G.I. Research

      Volume: 17巻 Pages: 87-88

    • Related Report
      2013 Final Research Report
  • [Journal Article] ING2 is upregulated in colon cancer and increases invasion by enhanced MMP13 expression2009

    • Author(s)
      Kumamoto K、Fujita K、Kurotani R、Saito M、Unoki M、Hagiwara N、Shiga H、Bowman ED、Yanaihara N、Okamura S、Nagashima M、Miyamoto K、Takenoshita S、Yokota J、Harris CC
    • Journal Title

      Int J Cancer

      Volume: 125巻 Pages: 1306-1315

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reviewing the currentclassification of inhibitor of growth family proteins2009

    • Author(s)
      Unoki M、Kumamoto K、Takenoshita S、Harris CC
    • Journal Title

      Cancer Sci

      Volume: 100巻 Pages: 1173-1179

    • NAID

      10027191680

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] ING22009

    • Author(s)
      隈元謙介
    • Journal Title

      G.I.Research 17

      Pages: 87-88

    • Related Report
      2009 Annual Research Report
  • [Journal Article] ING2 is upregulated in colon cancer and increases invasion by enhanced MMP13 expression2009

    • Author(s)
      隈元謙介, et al.
    • Journal Title

      Int J Cancer 125

      Pages: 1306-1315

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 食道癌に対する放射線化学療法の効果予測因子としてのInhibitor of Growth2(ING2)2011

    • Author(s)
      中村泉, 隈元謙介, ほか
    • Organizer
      日本癌治療学会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2011-10-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] 当科におけるStageIV大腸癌の治療成績の検討2011

    • Author(s)
      隈元謙介、石橋敬一郎、天野邦彦、桑原公亀、大澤智徳、岡田典倫、岩間毅夫、石田秀行
    • Organizer
      第66回日本大腸肛門病学会学術集会
    • Related Report
      2013 Final Research Report
  • [Presentation] 大腸癌におけるTS,ERCC1遺伝子発現とFOLFOX治療効果の検討2011

    • Author(s)
      隈元謙介, 石橋敬一郎, 岡田典倫, 田島雄介, 幡野哲, 天野邦彦, 桑原公亀, 大澤智徳, 芳賀紀裕, 石田秀行
    • Organizer
      第111回日本外科学会定期学術集会
    • Place of Presentation
      (誌上開催)
    • Related Report
      2013 Final Research Report
  • [Presentation] PD1-14下部直腸癌に対する術前化学放射線療法の有用性の検討と治療予測因子の探索2009

    • Author(s)
      隈元謙介、門馬智之、鈴木聡、中村泉、大木進司、竹之下誠一
    • Organizer
      第64回日本大腸肛門病学会学術集会
    • Related Report
      2013 Final Research Report

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Published: 2009-04-01   Modified: 2019-07-29  

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