| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2013: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2012: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2011: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Research Abstract |
The biological significance of the ING2 gene expression in colon cancer will be clarified by in vitro experiments using colon cancer cell lines. The aim of this study is to develop the molecules target treatment in clinical practice. In immunohistochemical analysis of ING2 with 130 colorectal cancer, the strong staining was observed in 78 (60%) cases. Overexpression of ING2 induced MMP13 mRNA expression using a colon cancer cell line, HCT116, into which adenoviral ING2 expression vector was transfected, in cDNA microarray analysis. ING2 overexpressed cells acquired the ability of invasion, leading to suggest that enhanced ING2 expression in colorectal cancer might be associated with cellular invasion and metastasis. Weak expression of ING2 was associated with the effect of preoperative chemoradiotherapy for advanced lower rectal cancer. Therefore ING2 could be the useful marker for the effect of preoperative chemoradiotherapy for advanced lower rectal cancer.
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