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Regeneration of fully circular and soft walled intestine with peristalsis using amniotic membrane-in dog experiment

Research Project

Project/Area Number 21591737
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionDoshisha University

Principal Investigator

HAGIWARA Akeo  同志社大学, 生命医科学部, 教授 (90198648)

Co-Investigator(Kenkyū-buntansha) 中村 達雄  京都大学, 再生医科学研究所, 准教授 (70227908)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords小腸大腸肛門外科学 / 再生医学 / 腸管再生 / 羊膜
Research Abstract

Amniotic membrane is one of an useful material for regeneration of fully circular walled intestine with peristalsis. Considering its difficulty in clinical application, however, we have devised another material of thermally cross-linked gelatin membrane instead of amniotic membrane. The examinations using rats and dogs have revealed that the thermally cross-linked gelatin membrane effectively prevents adhesions and regenerates the intestinal wall including peritoneum by providing with high performing scaffolds for tissue-regeneration.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (12 results)

All 2012 2011 2010 2009

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (5 results)

  • [Journal Article] Endocrine differentiation of rat enterocytes in long-term three-dimensional co-culture with intestinal myofibroblasts2011

    • Author(s)
      Tetsuji Yoshikawa, Shinichi Hamada, Eigo Otsuji, Tsujimoto Hiroyuki, Akeo Hagiwara
    • Journal Title

      In Vitro Cell. Dev. Biol.-Animal

      Volume: 47 Pages: 707-715

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of a novel anti-adhesive material, alginate flakes, ex Vivo and in Vivo2011

    • Author(s)
      Yoshinori Hirasaki, Masaki Fukunaga, Akio Kidokoro, Ayumi Hashimoto, Tstsuo Nakamura, Hiroyuki Tujimoto, Akeo Hagiwara
    • Journal Title

      Surgery Today

      Volume: 41 Pages: 970-977

    • NAID

      10029048751

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 新規癒着防止材熱架橋ゼラチンフィルムの物理的・生物化学的特性.癒着防止効果の機序及び腸管吻合部への影響に対する基礎的検討2011

    • Author(s)
      丹澤あゆみ、辻本洋行、的場麻里、橋本歩、鈴木周子、森田真一郎、筏義人、萩原明郎
    • Journal Title

      理工学研究報告

      Volume: 52 Pages: 149-155

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Endocrine differentiation of rat enterocytes in long-term three-dimensional co-culture with intestinal myofibroblasts2011

    • Author(s)
      Tetsuji Yoshikawa, Shinichi Hamada, Eigo Otsuji, Tsujimoto Hiroyuki, Akeo Hagiwara
    • Journal Title

      In Vitro Cell.Dev.Biol.--Animal

      Volume: 47 Pages: 707-715

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 新規癒着防止材熱架橋ゼラチンフィルムの物理的・生物化学的特性-癒着防止効果の機序及び腸管吻合部への影響に対する基礎的検討-2011

    • Author(s)
      丹澤あゆみ、辻本洋行、的場麻里、橋本歩、鈴木周子、森田真一郎、筏義人、萩原明郎
    • Journal Title

      理工学研究報告

      Volume: 52 Pages: 149-155

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of a novel anti-adhesive material, alginate flakes, ex vivo and in vivo2011

    • Author(s)
      Hirasaki Y, Fukunaga M, Kidokoro A, Hashimoto A, Nakamura T, Tsujimoto H, Hagiwara A
    • Journal Title

      Surgery Today

      Volume: (In press)

    • NAID

      10029048751

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regeneration of peritoneum using amniotic membrane to prevent postoperative adhesions2009

    • Author(s)
      Kuriu Y., Yamagishi H., Otsuji E., Hagiwara A.
    • Journal Title

      Hepato-Gastroenterology 56

      Pages: 1064-1068

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 熱架橋gelatin filmを用いた癒着防止と消化管吻合部えの影響-その腹膜再生効果と物理的・生物学的特性について2012

    • Author(s)
      辻本洋行、丹澤あゆみ、橋本歩、的場麻理、竹本洋一、石橋治昭、鈴木周子、森田真一郎、筏義人、萩原明郎
    • Organizer
      第112回日本外科学会定期学術集会
    • Place of Presentation
      幕張メッセ(千葉市)
    • Year and Date
      2012-04-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] 熱架橋gelatin filmを用いた癒着防止と消化管吻合部への影響-その腹膜再生効果と物理的・生物学的特性について-DDWJ2011

    • Author(s)
      辻本洋行、丹澤あゆみ、橋本歩、的場麻理、竹本洋一、石橋治昭、鈴木周子、森田真一郎、筏義人、萩原明郎
    • Place of Presentation
      横浜市
    • Year and Date
      2011-10-14
    • Related Report
      2011 Final Research Report
  • [Presentation] 腹部外科における癒着防止2010

    • Author(s)
      萩原明郎
    • Organizer
      第7回再生医療材料研究会
    • Place of Presentation
      メルパルク京都(京都府)
    • Year and Date
      2010-10-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] 熱架橋gelatin filmを用いた癒着防止と腹膜再生2010

    • Author(s)
      辻本洋行
    • Organizer
      第8回日本消化器外科学会大会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2010-10-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] 損傷腹膜の足場提供による腹腔内臓器癒着防止材の開発2010

    • Author(s)
      萩原明郎
    • Organizer
      第65回日本消化器外科学会総会
    • Place of Presentation
      海峡メッセ下関・下関市民会館(山口県)
    • Year and Date
      2010-07-15
    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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