The impact and clinical significance of mesenchymal stem cell in the process of metastasis in pancreatic cancer.

• Project/Area Number: 21591775
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Kyushu University
• Principal Investigator: UEDA Junji 九州大学, 大学病院, 助教 (90529801)
• Co-Investigator(Kenkyū-buntansha): EGAMI Takuya 九州大学, 大学院・医学研究院, 共同研究員 (40507787) ; TANAKA Masao 九州大学, 大学院・医学研究院, 教授 (30163570) ; OHUCHIDA Kenoki 九州大学, 大学院・医学研究院, 講師 (20452708)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 膵臓外科学 / 膵癌 / EMT / miRNA / Redox / 間葉系幹細胞 / 膵星細胞 / 間様系幹細胞

Research Abstract

We clarified that pancreatic stellate cells expressing mesenchymal stem cell marker enhanced the invasion and migration of pancreatic cancer cell in the cancer initiation and metastasis. Pancreatic cancer cells construct useful niche by which they stimulate the stromal cells. Inhibition of the molecules which are involved with the interaction between cancer cells and pancreatic stellate cells expressing mesenchymal stem cell marker controls pancreatic cancer progression.

Research Products

• [Journal Article] CD10+ pancreatic stellate cells enhance the progression of the pancreatic cancer (2010)
  • Author(s): Ikenaga N Ohuchida K, Mizumoto K, Cui L, Kayashima T, Morimatsu K, Moriyama T, Nakata K, Fujita H and Tanaka M
  • Journal Title: Gastroenterology Volume: 139 Pages: 1041-1051
• [Journal Article] Enhanced cell migration and invasion of CD133+ pancreatic cancer cells cocultured with pancreatic stromal cells (2010)
  • Author(s): Moriyama T, Ohuchida K, Mizumoto K, Cui L, Ikenaga N, Sato N and Tanaka M
  • Journal Title: Cancer Volume: 116 Pages: 3357-3368
• [Journal Article] CD10+ pancreatic stellate cells enhance the progression of the pancreatic cancer. (2010)
  • Author(s): Naoki Ikenaga, Kenoki Ohuchida, Kazuhiro Mizumoto, Lin Cui, Tadashi Kayashima, Taiki Moriyama, Kohei Nakata, Hayato Fujita, Masao Tanaka
  • Journal Title: Gastroent erology Volume: 139 Pages: 1041-1051
  • Peer Reviewed
• [Journal Article] Enhanced cell migration and invasion of CD133+ pancreatic cancer cellscocultured with pancreatic stromal cells. (2010)
  • Author(s): Taiki Moriyama, Kenoki Ohuchida, Kazuhiro Mizumoto, Lin Cui, Naoki Ikenaga, Norihiro Sato, Masao Tanaka
  • Journal Title: Cancer Volume: 116 Pages: 3357-3368
  • Peer Reviewed
• [Presentation] 浮遊条件で培養した膵癌由来線維芽細胞は膵癌細胞の悪性度を高める (2011)
  • Author(s): Lin Cui., et al
  • Organizer: 第111回日本外科学会定期学術集会
  • Place of Presentation: (東日本大地震のため紙上開催)
  • Year and Date: 2011-05-26
• [Presentation] CD10+ pancreatic stellate cells enhance the progression of the pancreatic cancer (2011)
  • Author(s): Ikenaga N
  • Organizer: 42nd Annual Meeting of the American Pancreatic Association
  • Place of Presentation: Chicago, USA
• [Presentation] The CD271 positive rate of pancreatic stellate cells is correlated with their migration activities enhanced by co-cultured pancreatic cancercells (2011)
  • Author(s): Fujiwara K, et al
  • Organizer: 3rdBiennialAsian-PacificHepato-Pancreato-BiliaryAssociation Congress
  • Place of Presentation: Melbourne, Australia
• [Presentation] Pancreatic Stellate Cells Promote Migration of CD105+ Pancreatic Cancer Cells (2011)
  • Author(s): Fujiwara K, et al
  • Organizer: 42nd American Pancreatic Association(APA) Annual Meeting
  • Place of Presentation: Chicago, USA
• [Presentation] CD10 positive pancreatic stellate cells enhance the progression of pancreatic cancer (2011)
  • Author(s): Ikenaga N, et al
  • Organizer: 42nd Annual Meeting of the American Pancreatic Association
  • Place of Presentation: Chicago, USA
• [Presentation] The CD271 positive rate of pancreatic stellate cells is correlated with their migration activities enhanced by co-cultured pancreatic cancer cells (2011)
  • Author(s): Fujiwara K., et al
  • Organizer: the 3rd Biennial Asian-Pacific Hepato-Pancreato-Biliary Association Congress 2011 (APHPBA 2011)
  • Place of Presentation: Melbourne, Australia
• [Presentation] CD10陽性膵星細胞は膵癌の進展を促進する (2010)
  • Author(s): 池永直樹、大内田研宙、水元一博、田中雅夫
  • Organizer: 第110回日本外科学会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-04-08