The impact and clinical significance of mesenchymal stem cell in the process of metastasis in pancreatic cancer.
| Project/Area Number |
21591775
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
UEDA Junji 九州大学, 大学病院, 助教 (90529801)
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| Co-Investigator(Kenkyū-buntansha) |
EGAMI Takuya 九州大学, 大学院・医学研究院, 共同研究員 (40507787)
TANAKA Masao 九州大学, 大学院・医学研究院, 教授 (30163570)
OHUCHIDA Kenoki 九州大学, 大学院・医学研究院, 講師 (20452708)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 膵臓外科学 / 膵癌 / EMT / miRNA / Redox / 間葉系幹細胞 / 膵星細胞 / 間様系幹細胞 |
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| Research Abstract |
We clarified that pancreatic stellate cells expressing mesenchymal stem cell marker enhanced the invasion and migration of pancreatic cancer cell in the cancer initiation and metastasis. Pancreatic cancer cells construct useful niche by which they stimulate the stromal cells. Inhibition of the molecules which are involved with the interaction between cancer cells and pancreatic stellate cells expressing mesenchymal stem cell marker controls pancreatic cancer progression.
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Report
(4 results)
Research Products
(11 results)
