| Project/Area Number |
21591781
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Saitama Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KOYAMA Isamu 埼玉医科大学, 医学部, 教授 (60178390)
AIKAWA Masayasu 埼玉医科大学, 医学部, 講師 (20438823)
OKADA Katsuya 埼玉医科大学, 医学部, 助教 (60364775)
鳥井 孝宏 埼玉医科大学, 医学部, 助教 (50364774)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 胆管狭窄 / 胆管再生 / 生体吸収性ステント / 胆道ステント / 生体吸収ポリマー / チューブステント / 胆管上皮 |
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| Research Abstract |
Development of a bioabsorbable stent to treat benign biliary stenosis
We have been developing bioabsorbable biliary stents made of polyglycolic acid that degrade within the body after having propped the narrowed bile duct open for a certain period of time. In pig's experiments, histology demonstrated good epithelial regeneration in the narrowed area of bile ducts, while none of the animals showed biliary enzyme elevation on blood chemistry. The stent is being tested in an increasing number of animals with encouraging results. This bioabsorbable stent seems useful for treatment of benign biliary stenosis.
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