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Clinical study on adoptive immunotherapy with autologous gammadelta T-lymphocyte for patients with pulmonary metastasis from colorectal cancer.

Research Project

Project/Area Number 21591809
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionThe University of Tokyo

Principal Investigator

NAKAJIMA Jun  東京大学, 医学部附属病院, 教授 (90188954)

Co-Investigator(Kenkyū-buntansha) KAKIMI Kazuhiro  東京大学, 医学部附属病院, 特任准教授 (80273358)
MURKAWA Tomohiro  東京大学, 医学部附属病院, 講師 (50359626)
FUKAMI Takeshi  東京大学, 医学部附属病院, 助教 (40396742)
YOSHIDA Yukihiro  東京大学, 医学部附属病院, 特任助教 (00529050)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords転移性肺腫瘍 / 結腸直腸癌 / 術後合併療法 / 免疫療法 / 自己活性化リンパ球療法 / γδT細胞 / 結腸・直腸癌
Research Abstract

Patients with pulmonary metastasis from colorectal cancer, which is an advanced form of the disease, can be cured by surgical resection. However, they are much likely to suffer from the recurrence. We performed a clinical trial of adoptive immunotherapy on the patients after curative resection of pulmonary metastasis from colorectal cancer ; gamma-delta fraction of T-lymphocytes was retrieved from the patients, incubated/activated in vitro, and then returned to the same patients. This treatment was able to carried out safely. Compared with the historical control group, there was no significant difference in survival rate or recurrence-free survival.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (36 results)

All 2012 2011 2010 2009 Other

All Journal Article (13 results) (of which Peer Reviewed: 12 results) Presentation (15 results) Book (5 results) Remarks (3 results)

  • [Journal Article] γδT-cell immunotherapy for lung cancer2011

    • Author(s)
      Yoshida Y, Nakajima J, Wada H, Kakimi K
    • Journal Title

      Surgery Today

      Volume: 41巻 Pages: 606-611

    • NAID

      10029047060

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adoptive immunotherapy for advanced non-small cell lung cancer using zoledronate-expandedγδTcells : a phase I clinical study2011

    • Author(s)
      Sakamoto M, Nakajima J, Murakawa T, Kakimi K, et al.
    • Journal Title

      J Immunother

      Volume: 34巻 Pages: 202-211

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 結腸・直腸癌肺転移に対する自己γδT細胞による術後補助免疫療法(会議録)2011

    • Author(s)
      中島淳, 村川知弘, 長山和弘, 佐野厚, 吉田幸弘, 北野健太郎, 井上雄太, 此枝千尋, 松下博和, 垣見和宏
    • Journal Title

      肺癌

      Volume: 51 Pages: 432-432

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 肺癌において期待される新しい治療肺がんに対する免疫療法(免疫細胞療法とがんペプチドワクチン療法)2011

    • Author(s)
      中島淳
    • Journal Title

      カレントテラピー

      Volume: 29 Pages: 1039-1044

    • Related Report
      2011 Annual Research Report
  • [Journal Article] γδT-cell immunotherapy for lung cancer2011

    • Author(s)
      Yoshida Y, Nakajima J, Wada H, Kakimi K
    • Journal Title

      Surgery today

      Volume: 41(5) Issue: 5 Pages: 606-11

    • DOI

      10.1007/s00595-010-4478-7

    • NAID

      10029047060

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adoptive immunotherapy for advanced non-small cell lung cancer using zoledronate-expanded γδTcells : a phase I clinical study2011

    • Author(s)
      Sakamoto M, Nakajima J, Murakawa T, Fukami T, Yoshida Y, Murayama T, Takamoto S, Matsushita H, Kakimi K
    • Journal Title

      Journal of Immunotherapy

      Volume: 34 Pages: 22-211

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adoptive immunotherapy for advanced non-small cell lung cancer using zoledronate-expanded yfi Tcells : a phase I clinical study.2011

    • Author(s)
      Sakamoto M, Nakajima J, Mura kawa T, Kakimi K, et al.
    • Journal Title

      J Immunother

      Volume: 34 Pages: 202-211

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A phase I study of adoptive immunotherapy for recurrent non-small cell lung cancer patients with autologous gammadelta T cells. A phase I study of adoptive immunotherapy for recurrent non-small cell lung cancer patients with autologous□gammadelta T cells2010

    • Author(s)
      Nakajima J, Murakawa T, Fukami T, Goto S, Kaneko T, Yoshida Y, Takamoto S, Kakimi K
    • Journal Title

      Eur J Cardio-Thorac Surg

      Volume: 37巻 Pages: 1191-1197

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A phase I study of adoptive immunotherapy for recurrent non-small-cell lung cancer patients with autologous gammadelta T cells.2010

    • Author(s)
      Nakajima J, Murakawa T, Kakimi K, et al.
    • Journal Title

      Eur J Cardio-Thorac Surg

      Volume: 37 Pages: 1191-1197

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A phase I study of adoptive immunotherapy for recurrent non-small cell lung cancer patients with autologous gammadelta T cells.2010

    • Author(s)
      中島淳, Murakawa T, Fukami T, Goto S, Kaneko T, 吉田幸弘, Takamoto S, Kakimi K
    • Journal Title

      European Journal of Cardio-Thoracic Surgery 37(In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Active specific immunotherapy and cell-transfer therapy for the treatment of non-small cell lung cancer2009

    • Author(s)
      Kakimi K, Nakajima J, Wada H.
    • Journal Title

      Lung Cancer

      Volume: 65巻 Pages: 1-8

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Active specific immunotherapy and cell-transfer therapy for the treatment of non-small cell lung cancer.2009

    • Author(s)
      Kakimi K, 中島淳, 和田洋巳
    • Journal Title

      Lung Cancer 65

      Pages: 1-8

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 原発性肺癌に対するがんワクチン治療2009

    • Author(s)
      杉浦未紀, 吉田幸弘, 中島淳, 垣見和宏, 和田洋巳
    • Journal Title

      肺癌 49

      Pages: 823-830

    • NAID

      130000123020

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Postoperative adjuvant immunotherapy with autologous gammadelta T-lymphocytes for patients suffering from pulmonary metastasis of colo-rectal cancer2012

    • Author(s)
      Nakajima J, Murakawa T, Nagayama K, Sano A, Yoshida Y, Kitano K, Matsuhsita H, Kakimi K.
    • Organizer
      Asian Society for Cardiovascular & Thoracic Surgery, annual meeting 2012
    • Place of Presentation
      Bali, Indonesia
    • Year and Date
      2012-03-09
    • Related Report
      2011 Final Research Report
  • [Presentation] 結腸・直腸癌肺転移に対する自己γδT細胞による術後補助免疫療法2011

    • Author(s)
      中島淳, 村川知弘, 長山和弘, 佐野厚, 吉田幸弘, 北野健太郎, 井上雄太, 此枝千尋, 松下博和, 垣見和宏
    • Organizer
      第52回日本肺癌学会総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2011-11-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] 結腸・直腸癌肺転移に対する自己γδT細胞による術後補助免疫療法2011

    • Author(s)
      中島淳,村川知弘,長山和弘,佐野厚,吉田幸弘,北野健太郎,井上雄太,此枝千尋,松下博和,垣見和宏
    • Organizer
      第52回日本肺癌学会総会
    • Place of Presentation
      大阪市
    • Year and Date
      2011-11-03
    • Related Report
      2011 Final Research Report
  • [Presentation] 非小細胞肺癌に対するγδT細胞療法の臨床研究2010

    • Author(s)
      中島淳
    • Organizer
      第51回日本肺癌学会総会
    • Place of Presentation
      広島市
    • Year and Date
      2010-11-03
    • Related Report
      2011 Final Research Report
  • [Presentation] 他自己活性化γδT細胞による非小細胞肺癌免疫療法2010

    • Author(s)
      吉田幸弘、村川知弘、中島淳、垣見和宏
    • Organizer
      日本癌治療学会総会
    • Place of Presentation
      京都市
    • Year and Date
      2010-10-30
    • Related Report
      2011 Final Research Report
  • [Presentation] 自己活性化γδT細胞による非小細胞肺癌免疫療法2010

    • Author(s)
      吉田幸弘、村川知弘、中島淳、垣見和宏, 他
    • Organizer
      日本癌治療学会総会
    • Place of Presentation
      京都市国立京都国際会館
    • Year and Date
      2010-10-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] 他γδT細胞治療に用いるγδT細胞とその体内動態2010

    • Author(s)
      有吉直子、垣見和弘
    • Organizer
      第14回日本がん免疫学会総会
    • Place of Presentation
      熊本市
    • Year and Date
      2010-07-22
    • Related Report
      2011 Final Research Report
  • [Presentation] γδT細胞治療に用いるγδT細胞とその体内動態2010

    • Author(s)
      有吉直子, 垣見和宏, 他
    • Organizer
      第14回日本がん免疫学会総会
    • Place of Presentation
      熊本市KKRホテル熊本
    • Year and Date
      2010-07-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 肺癌に対する免疫細胞治療-ワクチン治療と細胞移入治療2010

    • Author(s)
      垣見和宏
    • Organizer
      第158回日本肺癌学会関東支部会
    • Place of Presentation
      東京都
    • Year and Date
      2010-06-26
    • Related Report
      2011 Final Research Report
  • [Presentation] 肺癌に対する免疫細胞治療・ワクチン治療と細胞移入治療-2010

    • Author(s)
      垣見和宏
    • Organizer
      第158回日本肺癌学会関東支部会(ランチョンセミナー)
    • Place of Presentation
      東京都新宿区京王ブラザホテル
    • Year and Date
      2010-06-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 非小細胞肺癌に対するγδT細胞療法の臨床研究2010

    • Author(s)
      中島淳
    • Organizer
      第51回日本肺癌学会総会(ランチョンセミナー)
    • Place of Presentation
      広島市広島国際会議場
    • Year and Date
      2010-01-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 自己活性化γδT細胞による非小細胞肺癌免疫療法2009

    • Author(s)
      吉田幸弘,垣見和宏,金子亨,後藤重則,村川知弘,深見武史,杉浦未紀,中島淳
    • Organizer
      第47回日本癌治療学会総会
    • Place of Presentation
      横浜市
    • Year and Date
      2009-10-23
    • Related Report
      2011 Final Research Report
  • [Presentation] 自己活性化γδT細胞による非小細胞肺癌免疫療法(会議録)2009

    • Author(s)
      吉田幸弘, 垣見和宏, 金子亨, 後藤重則, 村川知弘, 深見武史, 杉浦未紀, 中島淳
    • Organizer
      第47回日本癌治療学会総会
    • Place of Presentation
      横浜市
    • Year and Date
      2009-10-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] Adoptive immunotherapy for recurrent non-small cell lung cancer patients with autologous gamma delta T-cells2009

    • Author(s)
      Nakajima J, Murakawa T, Fukami T, Kakimi K
    • Organizer
      European Association for Cardio-Thoracic Surgery(EACTS)
    • Place of Presentation
      ウィーン(オーストリア)
    • Year and Date
      2009-10-20
    • Related Report
      2011 Final Research Report
  • [Presentation] Adoptive immunotherapy for recurrent non-small cell lung cancer patients with autologous gammadelta T-cells.2009

    • Author(s)
      中島淳, 村川知弘, 深見武史, 垣見和宏
    • Organizer
      European Association for Cardio-Thoracic Surgery(EACTS)
    • Place of Presentation
      ウィーン(オーストリア)
    • Year and Date
      2009-10-20
    • Related Report
      2009 Annual Research Report
  • [Book] がんワクチン療法の進歩。Annual Review呼吸器20122012

    • Author(s)
      中島淳
    • Publisher
      中外医学社
    • Related Report
      2011 Final Research Report
  • [Book] 他(座談会)免疫療法は肺癌治療の選択肢に成りうるか? Lung Cancer Cutting Edge2012

    • Author(s)
      吉野一郎、中島淳、垣見和宏
    • Publisher
      株式会社アスカコーポレーション
    • Related Report
      2011 Final Research Report
  • [Book] がんワクチン療法の進歩Annual Review呼吸器2012巻Page254-2642012

    • Author(s)
      中島淳
    • Total Pages
      11
    • Publisher
      中外医学社
    • Related Report
      2011 Annual Research Report
  • [Book] (座談会)免疫療法は肺癌治療の選択肢に成りうるか?Lung Cancer Cutting Edge Vol 23 Page1-42012

    • Author(s)
      吉野一郎、本橋新一郎、中島淳、垣見和宏
    • Total Pages
      4
    • Publisher
      株式会社アスカコーポレーション
    • Related Report
      2011 Annual Research Report
  • [Book] 肺癌において期待される新しい治療肺がんに対する免疫療法(免疫細胞療法とがんペプチドワクチン療法)2011

    • Author(s)
      中島淳
    • Publisher
      カレントテラピー、ライフメディコム社
    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://ctstokyo.umin.ne.jp/thoracic/ts.htm

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://ctstokyo.umin.ne.jp/thoracic/research_ts_2.htm

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://ctstokyo.umin.ne.jp/thoracic/research_ts_2.htm

    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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