Toll-like receptor 4 mediates lung ischemia-reperfusion injury

• Project/Area Number: 21591811
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Mie University
• Principal Investigator: SHIMAMOTO Akira 三重大学, 医学部附属病院, 講師 (90324524)
• Co-Investigator(Renkei-kenkyūsha): TAKAO Motoshi 三重大学, 医学部附属病院, 准教授 (30263007) ; SHOMURA Shin 三重大学, 医学部附属病院, 医員 (70452224)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2011: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 外科 / 移植・再生医療 / シグナル伝達

Research Abstract

Ischemic preconditioning is mediated a MyD88-independent pathway, leading to NF-κB activation and protection against lung ischemia reperfusion injury. We conclude that an activation of MyD88 or TRIF, which are associate proteins of Toll-like receptor 4, would regulate a role of NF-κB to injure or preserve lung function.

Research Products

• [Journal Article] Invited commentary (2012)
  • Author(s): Shimamoto A
  • Journal Title: Ann Thorac Surg Volume: 93(1) Pages: 288-9
  • Peer Reviewed
• [Presentation] MyD88非依存経路を介した肺ischemic preconditioning現象の発症機序に関する研究 (2010)
  • Author(s): 島本亮、庄村心、高尾仁二、新保秀人
  • Organizer: 第27回日本呼吸器外科学会総会
  • Place of Presentation: 仙台市
  • Year and Date: 2010-05-13
• [Presentation] MyD88-independent signaling pathway is involved with lung ischemic preconditioning (2010)
  • Author(s): Shimamoto A, Yajima Y, Shomura S, Takao M, Shimpo H
  • Organizer: 30th Annual Meeting and Scientific Sessions of the International Society of Heart and Lung Transplantation
  • Place of Presentation: シカゴ・アメリカ合衆国
  • Year and Date: 2010-04-21
• [Presentation] MyD88-independent signaling pathway is involved with lung ischemic preconditioning. (2010)
  • Author(s): Shimamoto A
  • Organizer: 30^<th> International Society of Heart and Lung Transplantation
  • Place of Presentation: シカゴ・米国
  • Year and Date: 2010-04-21
• [Presentation] MyD88非依存経路を介した肺ischemic preconditioning現象の発症機序に関する研究 (2010)
  • Author(s): 島本亮、谷島義章、庄村心、高尾仁二、新保秀人
  • Organizer: 第26回日本肺および心肺移植研究会
  • Place of Presentation: 大阪市
  • Year and Date: 2010-01-30
• [Presentation] MyD88 dependent signaling pathway is involved with lung ischemia-reperfusion injury (2009)
  • Author(s): Shimamoto A, Yajima Y, Shomura S, Takao M, Shimpo H
  • Organizer: 29th Annual Meeting and Scientific Sessions of the International Society of Heart and Lung Transplantation
  • Place of Presentation: パリ・フランス
  • Year and Date: 2009-04-22
• [Presentation] MyD88 dependent signaling pathway is involved with lung ischemia-reperfusion injury (2009)
  • Author(s): Shimamoto A
  • Organizer: 29^<th> International Society of Heart and Lung Transplantation
  • Place of Presentation: パリ・フランス
  • Year and Date: 2009-04-22