Endovascular treatment of experimental aneurysms in swine model by use of mesenchymal stem cells-coated stents.

• Project/Area Number: 21591852
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Sapporo Medical University
• Principal Investigator: IIHOSHI Satoshi 札幌医科大学, 医学部, 助教 (60457710)
• Co-Investigator(Kenkyū-buntansha): HOUKIN Kiyohiro 札幌医科大学, 医学部, 教授 (90229146)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 移植再生医療 / 脳血管内治療 / 再生医学 / 神経科学 / 発生分化

Research Abstract

The purpose of this study was to determine whether implanting exogenous mesenchymal stem cells on stents could enhance aneurysmal neck healing. I thought hypotheses included that mesenchymal stem cells-coated stents can improve angiographic and histopathologic results after endovascular treatment. Mesenchymal stem cells-coated stents were not effective for accelerating organization of the aneurysms cavity and developing neointima after endovascular treatment. This is a promising novel procedure to repair aneurysm , and may provide a new way to induce plasticity in mesenchymal stem cells.