The change of regional cerebral blood flow during the epileptic discharge on epileptic rat models
Project/Area Number |
21591869
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Cerebral neurosurgery
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Research Institution | Osaka University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
SAITOH Yoichi 大阪大学, 産学連携本部, 特任教授(常勤) (20252661)
SHIMOSEGAWA Eku 大阪大学, 大学院・医学系研究科, 准教授 (30370258)
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Co-Investigator(Renkei-kenkyūsha) |
OSHINO Satoru 大阪大学, 大学院・医学系研究科, 助教 (40403050)
MARUO Tomoyuki 大阪大学, 大学院・医学系研究科, 医員 (90533810)
HOSOMI Koichi 大阪大学, 産学連携本部, 特任助教 (70533800)
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Project Period (FY) |
2009 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | てんかん / てんかん発作伝播 / 外科治療 / レーザースペックル血流計 / PET / 脳血流変化 / レーザースペックル血流測定計 / 緩和外科治療 / ラットモデル / FDG-PET / 統計学的解析 |
Research Abstract |
In this study, the changes of cerebral blood flow(CBF) were analyzed during the epileptic seizure using the rat models. The increase of CBF was observed with some partial seizures. Just before the secondary generalized seizure, once CBF decreased and it increased with the epileptic EEG. It demonstrates that depolarization wave might occurs before generalized seizure.
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Report
(4 results)
Research Products
(141 results)
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[Journal Article] Long-term developmental outcome in patients with West syndrome after epilepsy surgery2012
Author(s)
Iwatani Y, Kagitani-Shimono K, Tominaga K, Okinaga T, Mohri I, Kishima H, Kato A, Sanefuji W, Yamamoto T, Tatsumi A, Murata E, Taniike M, Nagai T, Ozono K
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Journal Title
Brain Dev
Volume: (In press)
Related Report
Peer Reviewed
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[Journal Article] Deep brain stimulation of the subthalamic nucleus improves temperature sensation in patients with Parkinson' s disease2011
Author(s)
Maruo T, Saitoh Y, Hosomi K, Kishima H, Shimokawa T, Hirata M, Goto T, Morris S, Harada Y, Yanagisawa T, Aly MM, Yoshimine T
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Journal Title
Pain
Volume: 152(4)
Pages: 860-5
Related Report
Peer Reviewed
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[Journal Article] Chronic implantation of newly developed suprachoroidal-transretinal stimulation(STS) prosthesis in dogs2011
Author(s)
Morimoto T, Kamei M, Nishida K, Sakaguchi H, Kanda H, Ikuno Y, Kishima H, Maruo T, Konoma K, Ozawa M, Nishida K, Fujikado T
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Journal Title
Invest Ophthalmol Vis Sci
Volume: 52(9)
Pages: 6785-92
Related Report
Peer Reviewed
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[Journal Article] Quantitative analysis of phosphenes induced by navigation-guided repetitive transcranial magnetic stimulation2011
Author(s)
Tani N, Hirata M, Motoki Y, Saitoh Y, Yanagisawa T, Goto T, Hosomi K, Kozu A, Kishima H, Yorifuji S, Yoshimine T
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Journal Title
Brain Stimul
Volume: 4(1)
Pages: 28-37
Related Report
Peer Reviewed
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[Journal Article] Testing of semichronically implanted retinal prosthesis by suprachoroidal-transretinal stimulation in patients with retinitis pigmentosa2011
Author(s)
Fujikado T, Kamei M, Sakaguchi H, Kanda H, Morimoto T, Ikuno Y, Nishida K, Kishima H, Maruo T, Konoma K, Ozawa M, Nishida K
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Journal Title
Invest Ophthalmol Vis Sci
Volume: 52(7)
Pages: 4726-33
Related Report
Peer Reviewed
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[Journal Article] Modulation of neuronal activity after spinal cord stimulation for neuropathic pain ; H(2) 15O PET study2010
Author(s)
Kishima H, Saitoh Y, Oshino S, Hosomi K, Ali M, Maruo T, Hirata M, Goto T, Yanagisawa T, Sumitani M, Osaki Y, Hatazawa J, Yoshimine T
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Journal Title
Neuroimage
Volume: 49(3)
Pages: 2564-9
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Peer Reviewed
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[Presentation] Provocative memory test for amygdalohippocampectomy using depth electrodes implanted in the entorhinal area2011
Author(s)
Tani N, Kishima H, Ali M, Oshino S, Hosomi K, Kui Ming K, Maruo T, Saitoh Y, Hirata M, Kato A, Kazui H, Yoshida T, Yoshimine T
Organizer
29th International Epilepsy Congress
Place of Presentation
Poster, Italy
Year and Date
2011-08-31
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[Presentation] Is the Additional Amygdalohippocampectomy Necessary for the Intractable Lesional Temporal Lobe Epilepsy2010
Author(s)
Kishima H, Oshino S, Hosomi K, Hirata M, Yanagisawa T, Goto T, Mohamed A, Shimono K, Okinaga T, Saitoh Y, Kato A
Organizer
The 4rd Asian Epilepsy Surgery Congress
Place of Presentation
Taipei, Taiwan
Related Report
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[Presentation] Quantitative analysis of 123I-iomazenil SPECT in temporal lobe epilepsy2010
Author(s)
Hosomi K, Kishima H, Oshino S, Hirata M, Mohammed A, Goto T, Maruo T, Yanagisawa T, Harada Y, Morris S, Kato A, Saitoh Y, Yoshimine T
Organizer
The 4rd Asian Epilepsy Surgery Congress
Place of Presentation
Taipei, Taiwan
Related Report
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[Presentation] Functional hemispherotomy by vertical method using neuronavigation2009
Author(s)
Kato A, Kishima H, Nakano N, Lin S, Shimono K, Okinaga T, Tsuyuguchi N, Oshino S, Ninomiya H, Hirata M, Yoshimine T
Organizer
The 3rd Asian Epilepsy Surgery Congress
Place of Presentation
Osaka, Japan
Related Report
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[Presentation] Occupational achievement after surgery for temporal lobe epilepsy2009
Author(s)
Kishima H, Oshino S, Hirata M, Hosomi K, Yanagisawa T, Goto T, Maruo T, Mohammed A, Kato A, Sitoh Y, Yoshimine T
Organizer
The 3rd Asian Epilepsy Surgery Congress
Place of Presentation
Osaka, Japan
Related Report
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[Presentation] Language dominance and mapping based on neuromagnetic oscillatory change : comparison with invasive procedures2009
Author(s)
Hirata M, Goto T, Barnes G, Kishima H, Oshino S, Yanagisawa T, Saitoh Y, Kato A, Hshimoto N, Yorifuji S, Yoshimine T
Organizer
The 3rd Asian Epilepsy Surgery Congress
Place of Presentation
Osaka, Japan
Related Report
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[Presentation] Quantitative analysis of 123I-iomazenil SPECT in temporal lobe epilepsy2009
Author(s)
Hosomi K, Kishima H, Oshino S, Hirata M, Goto T, Maruo T, Yanagisawa T, Mohammed A, Kato A, Saitoh Y, Yoshimine T
Organizer
The 3rd Asian Epilepsy Surgery Congress
Place of Presentation
Osaka, Japan
Related Report
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[Presentation] Alteration of interictal epileptic discharge after anterior corpus callosotomy2009
Author(s)
Oshino S, Kishima H, Hirata M, Hosomi K, Goto T, Yanagisawa T, Mohamed A, Maruo T, Saitoh Y, Kato A, Yoshimine T
Organizer
The 3rd Asian Epilepsy Surgery Congress
Place of Presentation
Osaka, Japan
Related Report
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[Presentation] Identification of epiliptogenic focus in patients with tuberous sclerosis complex using MEG ; Report of two cases2009
Author(s)
Mohamed A, Kishima H, Hosomi K, Oshino S, Hirata M, Yanagisawa T, Maruo T, Goto T, Saitoh Y, Kato A, Yoshimine T
Organizer
The 3rd Asian Epilepsy Surgery Congress
Place of Presentation
Osaka, Japan
Related Report
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