| Project/Area Number |
21591871
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Okayama University |
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Principal Investigator |
MIYOSHI Yasuyuki 岡山大学, 大学院・医歯薬学総合研究科, 講師 (00362997)
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| Co-Investigator(Kenkyū-buntansha) |
AGARI Takashi 岡山大学, 岡山大学病院, 助教 (60423290)
HISHIKAWA Tomohito 岡山大学, 岡山大学病院, 助教 (60509610)
KAMEDA Masahiro 岡山大学, 岡山大学病院, 医員 (50586427)
YASUHARA Takao 岡山大学, 岡山大学病院, 助教 (50457214)
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| Co-Investigator(Renkei-kenkyūsha) |
DATE Isao 岡山大学, 大学院・医歯薬学総合研究科, 教授 (70236785)
ICHKAWA Tomotsugu 岡山大学, 大学院・医歯薬学総合研究科, 助教 (10362964)
KUROZUMI Kazuhiko 岡山大学, 大学院・医歯薬学総合研究科, 助教 (20509608)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 脳深部電気刺激 / 酸化ストレス / 神経栄養因子 / 8-OHdG / ドパミン神経 / ドパミス神経 |
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| Research Abstract |
We analyzed the time dependent change of 8-OHdG level in PD disease model of animals. PD model of animals those have high level of 8-OHdG in the early stage would finally show more severe degeneration of dopaminergic neuron, which implies urinary 8-OHdG level can be a prominent biomarker for PD. Regarding clinical related research, we analyzed the relationship between oxidative stress and DBS in PD patients. We found the level of 8-OHdG level was decreased after DBS operation. That was why we concluded DBS could mitigate oxidative stress in PD patients.
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