Identification of chemo-resistant factors in glioblastomas, and construction of tailor-made treatment based upon these factors.
| Project/Area Number |
21591886
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Chiba Cancer Center (Research Institute) |
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Principal Investigator |
IUCHI Toshihiko 千葉県がんセンター(研究所), 脳神経外科, 部長 (80370881)
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|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 脳腫瘍学 / 神経膠芽腫 / MGMT / テモゾロミド / IMRT |
|---|
| Research Abstract |
Tailor-made treatment against glioblastomas owing to the methylation status of MGMT contributed to prevent radiation-injury after high-dose radiation. We extracted some genes whose expression level was significantly different between MGMT-methylated and-unmethylated tumors but could not find the correlation between the expression levels of these genes and chemo-resistant character of tumors.
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Report
(4 results)
Research Products
(21 results)
