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Experimental Study for Appropriate Medication for Osteoporotic Fragile Vertebral Fracture

Research Project

Project/Area Number 21591890
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionHokkaido University

Principal Investigator

ABUMI Kuniyoshi  北海道大学, 大学院・医学研究科, 教授 (00159419)

Co-Investigator(Kenkyū-buntansha) HOJO Yoshihiro  北海道大学, 北海道大学病院, 助教 (60451423)
OSHIMA Shigeki  北海道大学, 北海道大学病院, 助教 (90547613)
ABE Yuichiro  北海道大学, 北海道大学病院, 助教 (80547604)
TAKAHATA Masahiko  北海道大学, 北海道大学病院, 講師 (40374368)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywordsosteoporosis / vertebral fracture / medication / 骨代謝改善薬 / 骨折 / 骨移植 / 脊椎固定術 / 骨癒合過程 / 骨代謝 / 骨粗鬆症 / 脊椎骨折 / 構造解析
Research Abstract

Animal studies showed that major osteoporosis medication including bisphosphonate, selective estrogen receptor modulator, and teriparatide affects mode of bone healing but does not alter outcomes of fracture union or spinal arthrodesis surgery, suggesting that it is not necessarily to cease these osteoporosis medication after fracture or spine arthrodesis surgery.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (62 results)

All 2012 2011 2010 2009

All Journal Article (31 results) (of which Peer Reviewed: 20 results) Presentation (21 results) Book (10 results)

  • [Journal Article] Reconstruction of the subaxial cervical spine using pedicle screw instrumentation.2012

    • Author(s)
      Abumi K, Ito M. Sudo H.
    • Journal Title

      Spine

      Volume: 37 Pages: 349-356

    • NAID

      10031131101

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reconstruction of the subaxial cervical spine using pedicle screw instrumentation2012

    • Author(s)
      Abumi K, Ito M. Sudo H.
    • Journal Title

      Spine

      Volume: 37 Pages: 349-356

    • NAID

      10031131101

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel cost-effective computer-assisted imaging technology for accurate placement of thoracic pedicle screws2011

    • Author(s)
      Abe Y, Ito M, Abumi K, Kotani Y, Sudo H, Minami A
    • Journal Title

      J Neurosurg : Spine

      Volume: 15 Pages: 479-85

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mid-term clinical results of minimally invasive decompression and posterolateral fusion with percutaneous pedicle screws versus conventional approach for degenerative spondylolisthesis with spinal stenosis2011

    • Author(s)
      Kotani Y, Abumi K, Ito M, Sudo H, Abe Y, Minami A
    • Journal Title

      Eur Spine J

      Volume: 19 Suppl 2

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 頸椎部強直性脊椎骨粗鬆症増殖症における嚥下障害の病態とその対処2011

    • Author(s)
      伊東学、須藤英毅、鐙 邦芳、小谷善久、三浪明男
    • Journal Title

      脊椎脊髄

      Volume: 24 Pages: 191-196

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Mid-term clinical results of minimally invasive decompression and posterolateral fusion with percutaneous pedicle screws versus conventional approach for degenerative spondylolisthesis with spinal stenosis2011

    • Author(s)
      Kotani Y. Abumi K. Ito M, Sudo H, Abe Y, Minami A
    • Journal Title

      Eur Spine J

      Volume: 19 Suppl 2

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Occipitocervical fusion2010

    • Author(s)
      Abumi K, et al.
    • Journal Title

      Eur Spine J

      Volume: 19 Pages: 355-356

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Simultaneous double-rod rotation technique inposterior in strumentation suregery for correction of adolescent idiopathic scoliosis2010

    • Author(s)
      Ito M, Abumi K, et al.
    • Journal Title

      J Neurosurg Spine

      Volume: 12 Pages: 293-300

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] One-stage posterior instrumentation surgery for the treatment of osteoporotic vertebral collapse with neurologic deficits2010

    • Author(s)
      Sudo H, Ito M, Abumi K, et al.
    • Journal Title

      Eur Spine J

      Volume: 19 Pages: 907-915

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neurological recovery after surgical treatment of giant cervical pseudomeningoceles extending to lumbar spine associated with previous brachial plexus injury2010

    • Author(s)
      Kotani Y, Abumi k, et al.
    • Journal Title

      Eur Spine J

      Volume: 19

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A biomimetic artificial intervertebral disc system composed of acubic three-dimensional fabric.2010

    • Author(s)
      Shikinami Y, et al.
    • Journal Title

      Spine J.

      Volume: 10(2) Pages: 141-152

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Simultaneous double-rod rotation technique in posterior instrumentation suregery for correction of adolescent idiopathic scoliosis.2010

    • Author(s)
      Ito M, Abumi K, et al.
    • Journal Title

      J Neurosurg Spine

      Volume: 12 Pages: 293-300

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] One-stage posterior instrumentation surgery for the treatment of osteoporotic vertebral collapse with neurologic deficits.2010

    • Author(s)
      Sudo H, Ito M, Abumi K, et al.
    • Journal Title

      Eur Spine J

      Volume: 19 Pages: 907-915

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neurological recovery after surgical treatment of giant cervical pseudo meningoceles extending to lumbar spine associated with previous brachial plexus injury.2010

    • Author(s)
      Kotani Y, Abumi k, et al.
    • Journal Title

      Eur Spine J

      Volume: 19

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Occipitocervical fusion2010

    • Author(s)
      Abumi K
    • Journal Title

      Eur Spine J 19

      Pages: 355-356

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Simultaneous double-rod rotation technique in posterior instrumentation surgery for correction of adolescent idiopathic scoliosis2010

    • Author(s)
      Ito M
    • Journal Title

      J Neurosurg Spine 12

      Pages: 293-300

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] One-stage posterior instrumentation surgery of the treatment of osteoporotic vertebral collapse with neurological deficits2010

    • Author(s)
      Sudo H
    • Journal Title

      Eur Spine J 19(印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] リウマチ頚椎の手術治療の新展開2009

    • Author(s)
      鐙邦芳
    • Journal Title

      リウマチ科

      Volume: 42 Pages: 320-328

    • Related Report
      2011 Final Research Report
  • [Journal Article] 頚椎インプラントの現状2009

    • Author(s)
      鐙邦芳
    • Journal Title

      整形外科

      Volume: 60 Pages: 757-768

    • Related Report
      2011 Final Research Report
  • [Journal Article] 陳旧性胸椎・腰椎損傷に伴う後弯症2009

    • Author(s)
      鐙邦芳
    • Journal Title

      脊椎脊髄ジャーナル

      Volume: 22 Pages: 592-597

    • Related Report
      2011 Final Research Report
  • [Journal Article] 脊柱後弯症の矯正手術におけるinstrumentationの選択2009

    • Author(s)
      鐙邦芳
    • Journal Title

      脊椎脊髄ジャーナル

      Volume: 22 Pages: 482-485

    • Related Report
      2011 Final Research Report
  • [Journal Article] 脊柱後弯症の病態と矯正手術の基本概念2009

    • Author(s)
      鐙邦芳
    • Journal Title

      脊椎脊髄ジャーナル

      Volume: 22 Pages: 476-481

    • Related Report
      2011 Final Research Report
  • [Journal Article] リウマチ頚椎の手術治療の新展開2009

    • Author(s)
      鐙邦芳
    • Journal Title

      リウマチ科 42

      Pages: 320-328

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 頚椎インプラントの現状2009

    • Author(s)
      鐙邦芳
    • Journal Title

      整形外科 60

      Pages: 757-768

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 陳旧性胸椎・腰椎損傷に伴う後弯症2009

    • Author(s)
      鐙邦芳
    • Journal Title

      脊椎脊髄ジャーナル 22

      Pages: 592-597

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 脊柱後弯症の矯正手術におけるinstrumentationの選択2009

    • Author(s)
      鐙邦芳
    • Journal Title

      脊椎脊髄ジャーナル 22

      Pages: 482-485

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 脊柱後弯症の病態と矯正手術の基本概念2009

    • Author(s)
      鐙邦芳
    • Journal Title

      脊椎脊髄ジャーナル 22

      Pages: 476-481

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Minimally invasive surgery treatment for tuberculous spondylodiscitis2009

    • Author(s)
      Ito M
    • Journal Title

      Minim Invasive Neurosurg 52

      Pages: 250-253

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spinal cord compression by ligamentum flavum hematoma in the thoracic spine2009

    • Author(s)
      Sudo H
    • Journal Title

      Spine 34

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neurological recovery from pentaplegia after resection for sacral plasmacytoma presenting with POEMS syndrome2009

    • Author(s)
      Kotani Y
    • Journal Title

      J Neurosurg Spine 10

      Pages: 324-328

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Minimum 2-year outcome of cervical laminoplasty with deep extensor muscle-reserving approach2009

    • Author(s)
      Kotani Y
    • Journal Title

      Eur Spine J 18

      Pages: 663-671

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Cervical Osteotomies : How, when, where and why?2011

    • Author(s)
      Abumi K.
    • Organizer
      25^<th> Annual Meeting of Association of Spine Surgeons of India
    • Place of Presentation
      The Trident Hotel, Mumbai, India 招待講演
    • Related Report
      2010 Annual Research Report
  • [Presentation] Correction of cervical kyphosis using cervical pedicle screw fixation.2011

    • Author(s)
      Abumi K.
    • Organizer
      25^<th> Annual Meeting of Association of Spine Surgeons of India
    • Place of Presentation
      The Trident Hotel, Mumbai, India 招待講演
    • Related Report
      2010 Annual Research Report
  • [Presentation] Management of injury of the vertebral artery during surgery.2011

    • Author(s)
      Abumi K.
    • Organizer
      25^<th> Annual Meeting of Association of Spine Surgeons of Indiav
    • Place of Presentation
      The Trident Hotel, Mumbai, India 招待講演
    • Related Report
      2010 Annual Research Report
  • [Presentation] Management of injury of the vertebral artery during surgery2010

    • Author(s)
      Abumi K.
    • Organizer
      Instructional Course of The 38^<th> Annual Meeting of The Cervical Spine Research Society
    • Place of Presentation
      Charlotte, USA
    • Year and Date
      2010-12-01
    • Related Report
      2011 Final Research Report
  • [Presentation] Management of injury of the vertebral artery during surgery.2010

    • Author(s)
      Abumi K.
    • Organizer
      Instructional Course of The 38^<th> Annual Meeting of The Cervical Spine Research Society
    • Place of Presentation
      The Wesitin Charlotte, Charlotte, USA 招待講演
    • Year and Date
      2010-12-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] Historical Perspective and Evolution of Cervical Pedicle Screw Fixation2010

    • Author(s)
      Abumi K.
    • Organizer
      1^<st> Annual Meeting of Cervical Spine Research Society Asia-pacific Section
    • Place of Presentation
      Kobe International Conference Center, Kobe, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] Reconstruction of the subaxial cervical spine using pedicle screw instrumentation2010

    • Author(s)
      Abumi K
    • Organizer
      Combined Course of The 45^<th> Annual Meeting of Scoliosis Research Society
    • Place of Presentation
      Kyoto International Conference Center, Kyoto, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] Historical Perspective and Evolution of Cervical Pedicle Screw Fixation.2010

    • Author(s)
      Abumi K.
    • Organizer
      1^<st> Annual Meeting of Cervical Spine Research Society Asia-pacific Section
    • Place of Presentation
      Kobe International Conference Center, Kobe, Japan 招待講演
    • Related Report
      2010 Annual Research Report
  • [Presentation] Reconstruction of the subaxial cervical spine using pediclescrew instrumentation.2010

    • Author(s)
      Abumi K.
    • Organizer
      Combined Course of The 45^<th> Annual Meeting of Scoliosis Research Society
    • Place of Presentation
      Kyoto International Conference Center Kyoto, Japan 招待講演
    • Related Report
      2010 Annual Research Report
  • [Presentation] シンポジウム:胸椎後縦靭帯骨化症の手術治療2009

    • Author(s)
      鐙邦芳
    • Organizer
      第44回日本脊髄障害医学会
    • Place of Presentation
      東京国際フォーラム、東京都
    • Related Report
      2011 Final Research Report
  • [Presentation] パネルディスカッション:頚椎外傷に対する再建法2009

    • Author(s)
      鐙邦芳
    • Organizer
      第82回日本整形外科学会学術総会
    • Place of Presentation
      福岡国際会議場、福岡県
    • Related Report
      2011 Final Research Report
  • [Presentation] パネルディスカッション:上位頚椎,頚椎変形の治療2009

    • Author(s)
      鐙邦芳
    • Organizer
      第43回日本側彎症学会
    • Place of Presentation
      東京コンファレンスセンター、東京都
    • Related Report
      2011 Final Research Report
  • [Presentation] Indirect nerve decompre-ssionat the CV junction by realignment of occipitocervical spinal using cervical pedicle screw fixation systems : review of 154 patients2009

    • Author(s)
      Abumi K
    • Organizer
      25^<th> Annual Meeting of the Cervical Spine Research Society-European Section
    • Place of Presentation
      Uppsala, Sweden
    • Related Report
      2011 Final Research Report
  • [Presentation] Complicaiton in cervical spine surgeries : vertebral artery injury2009

    • Author(s)
      Abumi K
    • Organizer
      Spine Across the Sea : Combined Meeting of the North American spine Society and Japanese Society for SpineSurgery and Related Reseach
    • Place of Presentation
      Maui, Hawaii, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Progression of subaxial lesion after occipitocervical fixation : Review of 154 patients managed by cervical pedicle screw fixation2009

    • Author(s)
      Abumi K
    • Organizer
      37^<th> Annual Meeting of the Cervical Spine Research Society
    • Place of Presentation
      Salt Lake City, Utah, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] シンポジウム:胸椎後縦靭帯骨化症の手術治療2009

    • Author(s)
      鐙邦芳
    • Organizer
      第44回日本脊髄障害医学会
    • Place of Presentation
      東京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] パネルディスカッション:頚椎外傷に対する再建法2009

    • Author(s)
      鐙邦芳
    • Organizer
      第82回日本整形外科学会学術総会
    • Place of Presentation
      福岡市
    • Related Report
      2009 Annual Research Report
  • [Presentation] パネルディスカッション:上位頚椎,頚椎変形の治療2009

    • Author(s)
      鐙邦芳
    • Organizer
      第43回日本側彎症学会
    • Place of Presentation
      東京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] Indirect nerve decompression at the CV junction by realignment of occipitocervical spinal using cervical pedicle screw fixation systems : review of 154 patients2009

    • Author(s)
      Abumi K
    • Organizer
      25^<th> Annual Meeting of the Cervical Spine Research Society -European Section
    • Place of Presentation
      Uppsala, Sweden
    • Related Report
      2009 Annual Research Report
  • [Presentation] Complicaiton in cervical spine surgeries : vertebral artery injury2009

    • Author(s)
      Abumi K
    • Organizer
      Spine Across the Sea : Combined Meeting of the North American spine Society and Japanese Society for Spine Surgery and Related Reseach
    • Place of Presentation
      Maui, Hawaii USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] Progression of subaxial lesion after occipitocervical fixation : Review of 154 patients managed by cervical pedicle screw fixation2009

    • Author(s)
      Abumi K
    • Organizer
      37^<th> Annual Meeting of the Cervical Spine Research Society
    • Place of Presentation
      Salt Lake City, Utah USA
    • Related Report
      2009 Annual Research Report
  • [Book] Surgical Techniques2011

    • Author(s)
      Abumi K, Ito M, Kotani Y
    • Publisher
      Stuttgart-New York, Diagnosis, Pathology
    • Related Report
      2011 Final Research Report
  • [Book] Surgical Techniques.2011

    • Author(s)
      Abumi K
    • Total Pages
      574
    • Publisher
      Stuttgart-New York, The Craniovertebral Junction : Diagnosis, Pathology
    • Related Report
      2011 Final Research Report
  • [Book] Diagnosis, Pathology, Surgical Techniques2011

    • Author(s)
      Abumi K. Ito M, Kotani Y (共著)
    • Publisher
      Stuttgart-New York
    • Related Report
      2011 Annual Research Report
  • [Book] In Advanced Reconstruction : Spine2011

    • Author(s)
      Abumi K, Ito M, Kotani Y (共著)
    • Publisher
      Stuttgart-New York
    • Related Report
      2011 Annual Research Report
  • [Book] The Craniovertebral Junction : Diagnosis, Pathology, Surgical Techniques.2010

    • Author(s)
      Abumi K, et al.
    • Total Pages
      574
    • Publisher
      Stuttgart-New York
    • Related Report
      2010 Annual Research Report
  • [Book] 手術進入法と基本手術手技-脊椎・脊髄2009

    • Author(s)
      鐙邦芳
    • Total Pages
      12
    • Publisher
      中山書店
    • Related Report
      2011 Final Research Report
  • [Book] Jaypee, Emerging Techni ques in Spine Surgery2009

    • Author(s)
      Abumi K
    • Total Pages
      12
    • Related Report
      2011 Final Research Report
  • [Book] Cervical Spine Trauma2009

    • Author(s)
      Abumi K
    • Total Pages
      11
    • Publisher
      Rothman Institute
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Book] 最新整形外科学大系 第6巻 手術進入法と基本手術手技 -脊椎・脊髄2009

    • Author(s)
      鐙邦芳
    • Total Pages
      29
    • Publisher
      中山書店
    • Related Report
      2009 Annual Research Report
  • [Book] Emerging Techniques in Spine Surgery2009

    • Author(s)
      Abumi K
    • Total Pages
      12
    • Publisher
      Jaypee
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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