Role of MIF on the process of fracture healing and the effect of its regulation
| Project/Area Number |
21591909
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Hokkaido University |
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Principal Investigator |
ONODERA Shin 北海道大学, 大学院・医学研究科, 客員准教授 (00359481)
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| Co-Investigator(Kenkyū-buntansha) |
TOHYAMA Harukazu 北海道大学, 北海道大学病院, 准教授 (60301884)
YASUDA Kazunori 北海道大学, 大学院・医学研究科, 教授 (20166507)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 骨折治癒 / マクロファージ遊走阻止因子 / ノックアウトマウス / 構造特性 / 遺伝子発現 / 骨形態計測 / 力学試験 / 骨髄細胞 / 石灰化 |
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| Research Abstract |
We investigated the role of macrophage migration inhibitory factor (MIF) on the process of fracture healing using MIF KO mice. In MIF KO mice, the mechanical properties of the fracture callus were decreased at the early stage of fracture healing, which was caused at least in part by the delay in the calcification of osteoid or the decrease in the number of osteoclasts. These were considered to be associated with decreased mRNA expression of MMP-2, MT1-MMP, Cathepsin K, and alkaline phosphatase.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] DNA vaccination against macrophage migration inhibitory factor improves atopic dermatitis in murine models2009
Author(s)
Hamasaka A, Abe R, Koyama Y, Yoshioka N, Fujita Y, Hoshina D, Sasaki M, Hirasawa T, Onodera S, Ohshima S, Leng L, Bucala R, Nishihira J, Shimizu T, Shimizu H
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Journal Title
J Allergy Clin Immunol
Volume: 124(1)
Pages: 90-99
Related Report
Peer Reviewed
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