| Project/Area Number |
21591924
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
MARUMO Keishi 東京慈恵会医科大学, 医学部, 教授 (70199925)
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| Co-Investigator(Kenkyū-buntansha) |
SAITO Mitsuru 東京慈恵会医科大学, 医学部, 准教授 (50301528)
KUROSAKA Daizaburo 東京慈恵会医科大学, 医学部, 助教 (80297382)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | チタン細繊維 / 再建靱帯・骨接合部 / 移植腱 / LIPUS / 成熟促進 / チタン細線維 / 再建靭帯・骨接合部 |
|---|
| Research Abstract |
We performed reconstruction of the tendon-bone junction using the tubular titanium-web(TW) made from titanium microfibers. Four months postoperatively tendon-like and bone-like tissue ingrowth was observed within the TW in histological specimens. Furthermore, since maturity of the ingrowing tissue within the tendon matrix, the titanium-web and the bone was similar to the normal tissue, we confirmed that bone and tendon could be joined by the TW. The reconstruction occurred not because of impaired maturity of collagen, the main structural component of tendons and bones, but due to formation of a tissue matrix containing tissue-specific collagen cross-links patterns.
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