Crosstalk of TGF signal and TRAF signal in osteoclastogenesis

• Project/Area Number: 21591932
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: The University of Tokyo
• Principal Investigator: KADONO Yuho 東京大学, 医学部附属病院, 講師 (70401065)
• Co-Investigator(Kenkyū-buntansha): TANAKA Sakae 東京大学, 医学部附属病院, 教授 (50282661) ; YASUI Tetsuro 東京大学, 医学部附属病院, 特任助教 (30583108)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 骨・軟骨代謝学 / 破骨細胞 / 破骨細胞分化 / TGF-β

Research Abstract

We identified that TGF-beta is indispensable in osteoclastogenesis both in vitro and in vivo. We identified that Smad pathways, not non-Smad pathways, mediates the role of TGF-beta on osteoclastogenesis. We obtained the data indicating that Smad3 involves in TRAF6-TAB-TAK complex formation which exists in downstream of osteoclastogenic RANKL/RANK pathway.

Research Products

• [Journal Article] Regulation of RANKL-induced osteoclastogenesis by TGF-βthrough molecular interaction between Smad3 and Traf6 (2011)
  • Author(s): Tetsuro Yasui, Yuho Kadono, Masaki Nakamura, Yasushi Oshima, Takumi Matsumoto, Hironari Masuda1, Jun Hirose1, Yasunori Omata, Hisataka Yasuda, Takeshi Imamura, Kozo Nakamura, and Sakae Tanaka.
  • Journal Title: J Bone Miner Res Volume: 26(7) Pages: 1447-56
  • Peer Reviewed
• [Presentation] Epigenetic regulation of osteoclast (2011)
  • Author(s): Tanaka Sakae
  • Organizer: 4^<th> New York Skeletal Biology and Medicine
  • Place of Presentation: New York, USA
  • Year and Date: 2011-04-28
• [Presentation] Epigenetic regulation of osteoclast (2011)
  • Author(s): 田中栄
  • Organizer: 4th New York Skeletal Biology and Medicine
  • Place of Presentation: New York USA(招待講演)
  • Year and Date: 2011-04-28
• [Presentation] Involvement of TGF-beta in osteoclastogenesis (2010)
  • Author(s): 安井哲郎
  • Organizer: 第28回日本骨代謝学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2010-07-22
• [Presentation] Invovlement of TGF-beta in osteoclastogenesis (2010)
  • Author(s): Tetsuro Yasui
  • Organizer: 第28回日本骨代謝学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2010-07-21
• [Presentation] Regulation of RANKL-induced osteoclastogenesis by TGF-beta through molecular interaction between Smad2/3 and TRAF6 (2009)
  • Author(s): 安井哲郎, 門野夕峰, 田中栄
  • Organizer: American Society for Bone and Mineral Research 2009 Annual Meeting
  • Place of Presentation: デンバー(米国コロラド州)
  • Year and Date: 2009-09-11