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Crosstalk of TGF signal and TRAF signal in osteoclastogenesis

Research Project

Project/Area Number 21591932
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionThe University of Tokyo

Principal Investigator

KADONO Yuho  東京大学, 医学部附属病院, 講師 (70401065)

Co-Investigator(Kenkyū-buntansha) TANAKA Sakae  東京大学, 医学部附属病院, 教授 (50282661)
YASUI Tetsuro  東京大学, 医学部附属病院, 特任助教 (30583108)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords骨・軟骨代謝学 / 破骨細胞 / 破骨細胞分化 / TGF-β
Research Abstract

We identified that TGF-beta is indispensable in osteoclastogenesis both in vitro and in vivo. We identified that Smad pathways, not non-Smad pathways, mediates the role of TGF-beta on osteoclastogenesis. We obtained the data indicating that Smad3 involves in TRAF6-TAB-TAK complex formation which exists in downstream of osteoclastogenic RANKL/RANK pathway.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (6 results)

All 2011 2010 2009

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (5 results)

  • [Journal Article] Regulation of RANKL-induced osteoclastogenesis by TGF-βthrough molecular interaction between Smad3 and Traf62011

    • Author(s)
      Tetsuro Yasui, Yuho Kadono, Masaki Nakamura, Yasushi Oshima, Takumi Matsumoto, Hironari Masuda1, Jun Hirose1, Yasunori Omata, Hisataka Yasuda, Takeshi Imamura, Kozo Nakamura, and Sakae Tanaka.
    • Journal Title

      J Bone Miner Res

      Volume: 26(7) Pages: 1447-56

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] Epigenetic regulation of osteoclast2011

    • Author(s)
      Tanaka Sakae
    • Organizer
      4^<th> New York Skeletal Biology and Medicine
    • Place of Presentation
      New York, USA
    • Year and Date
      2011-04-28
    • Related Report
      2011 Final Research Report
  • [Presentation] Epigenetic regulation of osteoclast2011

    • Author(s)
      田中栄
    • Organizer
      4th New York Skeletal Biology and Medicine
    • Place of Presentation
      New York USA(招待講演)
    • Year and Date
      2011-04-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Involvement of TGF-beta in osteoclastogenesis2010

    • Author(s)
      安井哲郎
    • Organizer
      第28回日本骨代謝学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-07-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] Invovlement of TGF-beta in osteoclastogenesis2010

    • Author(s)
      Tetsuro Yasui
    • Organizer
      第28回日本骨代謝学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-07-21
    • Related Report
      2011 Final Research Report
  • [Presentation] Regulation of RANKL-induced osteoclastogenesis by TGF-beta through molecular interaction between Smad2/3 and TRAF62009

    • Author(s)
      安井哲郎, 門野夕峰, 田中栄
    • Organizer
      American Society for Bone and Mineral Research 2009 Annual Meeting
    • Place of Presentation
      デンバー(米国コロラド州)
    • Year and Date
      2009-09-11
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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