Elucidation of the roles of SDF-1/CXCR4 signaling on degenerative changes of articular cartilage

• Project/Area Number: 21591942
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Kyoto University
• Principal Investigator: ITO Hiromu 京都大学, 医学研究科, 准教授 (70397537)
• Co-Investigator(Renkei-kenkyūsha): TASHIRO Kei 京都府立医科大学, 医学研究科, 教授 (10263097) ; NAGASAWA Takashi 京都大学, 再生医科学研究所, 教授 (80281690) ; NAKAMURA Takashi 独立行政法人国立病院機構(京都医療センター臨床研究センター), 臨床研究企画運営部, 研究員 (10201675)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 変形性関節症 / 関節軟骨 / ケモカイン / SDF-1 / CXCR4

Research Abstract

We examined the roles of SDF-1/CXCR4 signaling on degenerative changes of articular cartilages. SDF-1 upregulated type II and type X collagen expression in mouse chondrocytes, but did not directly regulate mRNA expression of type X collagen. In mouse knee joint with osteoarthritic changes, SDF-1 and CXCR4 expression were upregulated. However, there were no significant osteoarthritis changes between wild-type and SDF-1+/. mice.

Research Products

• [Journal Article] Stromal cell-derived factor 1 regulates the actin organization of chondrocytes and chondrocyte hypertrophy (2012)
  • Author(s): Koichi Murata, Toshiyuki Kitaori, Shinya Oishi, Naoki Watanabe, Hiroyuki Yoshitomi, Shimei Tanida, Masahiro Ishikawa, Takashi Kasahara, Hideyuki Shibuya, Nobutaka Fujii, Takashi Nagasawa, Takashi Nakamura, Hiromu Ito
  • Journal Title: PLoS ONE Volume: 7(5)
  • URL: http://www.plosone.org/article/info%3A
  • Peer Reviewed
• [Journal Article] 骨治癒を促進させるケモカイン分子Stromal cell-derived factor 1 (SDF-1) (2010)
  • Author(s): 北折俊之、伊藤宣, 他
  • Journal Title: 臨床整形外科 45 Pages: 72-75
  • Peer Reviewed
• [Journal Article] Stromal Cell-Derived Factor/CXCR4 Signaling Is Critical for the Recruitment of Mesenchymal Stem Cells to the Fracture Site During Skeletal Repair in a Mouse Model (2009)
  • Author(s): Kitaori H, Ito H, et al
  • Journal Title: Arthritis and Rheumatism 60 Pages: 813-823
  • Peer Reviewed
• [Presentation] SDF-1はアクチン重合を制御して軟骨の肥大化を促進する (2011)
  • Author(s): 村田浩一、伊藤宣、中村孝志他
  • Organizer: 第24回日本軟骨代謝学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2011-03-05
• [Presentation] SDF-1はアクチン重合を制御して軟骨の肥大化を促進する (2011)
  • Author(s): 村田浩一、伊藤宣, 他
  • Organizer: 第24回日本軟骨代謝学会
  • Place of Presentation: 九州大学医学部百年講堂(福岡県)
  • Year and Date: 2011-03-05
• [Presentation] 骨治癒における間葵系幹細胞の誘導:ケモカインSDF-1の機能的役割 (2009)
  • Author(s): 北折俊之、伊藤宣、中村孝志
  • Organizer: 第27回日本骨代謝学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-07-23