Mechanisms of postoperative cognitive dysfunction after inhalation anesthesia
| Project/Area Number |
21591968
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Akita University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MASAKI Yoko 秋田大学, 医学研究科, 助教 (30125744)
KAWAMURA Koichi 秋田大学, 医学研究科, 准教授 (00091801)
ABE Kyoko 秋田大学, 医学部, 助教 (30311575)
NISHIKAWA Toshiaki 秋田大学, 医学研究科, 教授 (50156048)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 麻酔学 / 吸入麻酔薬 / 術後認知機能低下 / セボフルラン / プロポフォール / 術後認知機能障害 / イソフルラン / 脳 / 血液 / ガスクロマトグラフ / 内部標準法 / SIM分析 |
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| Research Abstract |
Residual subanesthetic concentration of an inhaled anesthetic may be associated with postoperative impairment of psychomotor and physiologic function. We measured sevoflurane concentrations in blood and brain in rats and blood in humans until 1 week after discontinuation of sevoflurane. Blood and brain in rats contained sevoflurane even 7 days after discontinuation of the anesthetic. The concentrations of sevoflurane in brain 7 days after anesthesia were approximately 6 times their blood concentrations. Blood in humans also contained sevoflurane even 7 days after sevoflurane anesthesia. On the other hand, Propofol disappeared in both blood and brain 2 days after propofol anesthesia.
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Report
(4 results)
Research Products
(22 results)
