Involvement of VIP Signaling in Right Cardiac Hypertrophy

• Project/Area Number: 21591981
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Yokohama City University
• Principal Investigator: WATANABE Itaru 横浜市立大学, 附属病院, 講師 (20534142)
• Co-Investigator(Kenkyū-buntansha): MIZUNO Yusuke 横浜市立大学, 医学部, 講師 (80433192) ; KAWAKAMI Hiromasa 横浜市立大学, 医学部, 助教 (90407958)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 右心肥大 / PACAP/VIP / 心臓神経叢 / 遺伝子治療 / レンチウイルス / 心肥大 / VIP / PACAP / プラスミドベクター

Research Abstract

Elevated PACAP but not VIP signaling was associated with right ventricular hypertrophy and heart failure induced with monocrotaline in rats. PACAP-preferring receptor PCAl and the common receptor VPAC2 were up-regulated in both ventricles. Thus, PACAP signaling may play a more predominant role during cardiac hypertrophy and hear failure.

Research Products

• [Journal Article] Altered expression in pituitary adenylate cyclase-activating Polypeptide and its receptors in monocrotaline - induced pulmonary hypertension in rats (2011)
  • Author(s): Mizuno Y, Koga M, Irie T, Goto T
  • Journal Title: Eur. J. Anaesthesiol Volume: Vol28 Pages: 67-67
  • Peer Reviewed
• [Presentation] Involvement of PACAP Signaling in Right Cardiac Hypertrophy Induced With Monocrotaline in Rats (2012)
  • Author(s): Motokazu Koga, Yusuke Mizuno, Hiromasa Kawakami, Itaru Watanabe, Takahisa Goto
  • Organizer: American Society of Anesthesiologists. Annual nleeting 2012
  • Place of Presentation: Washington, DC, USA
  • Year and Date: 2012-10-14
• [Presentation] Altered expression in pituitary adenylate cyclase-activatin polypeptide and its receptors in monocrotaline-induced pulmonary hypertension in rats (2011)
  • Author(s): Yusuke Mizuno
  • Organizer: European society of Anesthesiologysts, Annual Meeting
  • Place of Presentation: Amsterdam RAI Convention Centre, Netherland
  • Year and Date: 2011-06-12
• [Presentation] Altered Expression of VIP/VPAC2 in Hypertrophic Right Ventricle Induced with Monocrotaline in Rats (2010)
  • Author(s): Hiromasa Kawakami
  • Organizer: European Society of Anesthesiologists Annual meeting 2010
  • Place of Presentation: Helsinki Finland
  • Year and Date: 2010-06-13
• [Presentation] Altered Expression of VIP/VPAC2 in Hypertrophic Right Ventricle Induced with Monocrotaline in Rats (2009)
  • Author(s): Motokazu Koga, Hiromasa Kawakami, Yusuke Mizuno et al.
  • Organizer: American Society of Anesthesiologists Annual meeting 2009
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2009-10-20
• [Presentation] Altered Expression of VIP/VPAC2 in Hypertrophic Right Ventricle Induced with Monocrotaline in Rats (2009)
  • Author(s): Motokazu Koga
  • Organizer: American society of Anesthesiologysts, Annual Meeting 2009
  • Place of Presentation: New Orleans LA USA
  • Year and Date: 2009-10-20
• [Remarks] 横浜市立大学麻酔科ホームページに記載