Mechanisms of oxidative stress in the human arteries from patients with metabolic syndrome and the treatment using a gene therapy
| Project/Area Number |
21591985
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
IRANAMI Hiroshi 和歌山県立医科大学, 医学部, 臨床教授 (30193692)
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| Co-Investigator(Kenkyū-buntansha) |
KINOSHITA Hiroyuki 和歌山県立医科大学, 医学部, 准教授 (70291490)
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| Co-Investigator(Renkei-kenkyūsha) |
AZMA Toshiharu 埼玉医科大学, 医学部, 講師 (60284197)
HATAKEYAMA Noboru 愛知医科大学, 医学部, 教授 (70251907)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 麻酔学 / ヒト血管 / 平滑筋 / 高血糖 / NADPHオキシダーゼ / アクチン / ATP感受性カリウムチャネル |
|---|
| Research Abstract |
We prepared arterial rings with 2. 5 mm length of human omental arteries without endothelium. Exposure toward a high concentration of D-glucose(22. 5 mmol/L) reduced both relaxation and hyperpolarization in response to an ATP-sensitive K+channel opener. In human vascular smooth muscle cells exposed to high glucose, intracellular levels of superoxide in addition to expression of NADPH oxidase subunit p47phox on cellular membrane increased and they were accompanied by the enhanced F-actin ratio in the smooth muscle cells
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Report
(4 results)
Research Products
(19 results)
