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Mechanisms of oxidative stress in the human arteries from patients with metabolic syndrome and the treatment using a gene therapy

Research Project

Project/Area Number 21591985
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionWakayama Medical University

Principal Investigator

IRANAMI Hiroshi  和歌山県立医科大学, 医学部, 臨床教授 (30193692)

Co-Investigator(Kenkyū-buntansha) KINOSHITA Hiroyuki  和歌山県立医科大学, 医学部, 准教授 (70291490)
Co-Investigator(Renkei-kenkyūsha) AZMA Toshiharu  埼玉医科大学, 医学部, 講師 (60284197)
HATAKEYAMA Noboru  愛知医科大学, 医学部, 教授 (70251907)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords麻酔学 / ヒト血管 / 平滑筋 / 高血糖 / NADPHオキシダーゼ / アクチン / ATP感受性カリウムチャネル
Research Abstract

We prepared arterial rings with 2. 5 mm length of human omental arteries without endothelium. Exposure toward a high concentration of D-glucose(22. 5 mmol/L) reduced both relaxation and hyperpolarization in response to an ATP-sensitive K+channel opener. In human vascular smooth muscle cells exposed to high glucose, intracellular levels of superoxide in addition to expression of NADPH oxidase subunit p47phox on cellular membrane increased and they were accompanied by the enhanced F-actin ratio in the smooth muscle cells

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (19 results)

All 2011 2010 2009 Other

All Journal Article (10 results) (of which Peer Reviewed: 7 results) Presentation (8 results) Remarks (1 results)

  • [Journal Article] 高血糖病態が血管平滑筋機能に及ぼす影響2011

    • Author(s)
      木下浩之
    • Journal Title

      循環制御

      Volume: 32 Pages: 3-9

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 『静脈麻酔薬の作用機序:受容体と細胞内シグナル伝達機構』プロポフォール2011

    • Author(s)
      木下浩之
    • Journal Title

      Anesthesia 21 Century

      Volume: 13 Pages: 4-10

    • Related Report
      2011 Final Research Report
  • [Journal Article] 酸化ストレスからみた臓器保護:心不全と酸化ストレス2011

    • Author(s)
      木下浩之
    • Journal Title

      日本臨床麻酔学会雑誌

      Volume: 31 Pages: 116-123

    • NAID

      10027753115

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 酸化ストレスからみた臓器保護:心不全と酸化ストレス2011

    • Author(s)
      木下浩之
    • Journal Title

      日本臨床麻酔学会誌

      Volume: 31 Pages: 116-123

    • NAID

      10027753115

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ホスファチジルイノシトール3-キナーゼ-Akt経路と血管病態生理2010

    • Author(s)
      木下浩之
    • Journal Title

      Anesthesia 21 Century

      Volume: 12 Pages: 2309-2316

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Journal Article] The modulation of vascular ATP-sensitive K^+channel function via phosphatidylinosito 3-kinase-Akt pathway activated by phenylephrine2010

    • Author(s)
      Haba M, Hatakeyama N, Kinoshita H, Teramae H, Azma T, Hatano Y, Matsuda N
    • Journal Title

      J Pharmacol Exp Ther

      Volume: 334 Pages: 673-678

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 血管への酸化ストレスと麻酔薬2009

    • Author(s)
      木下浩之
    • Journal Title

      麻酔

      Volume: 58

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The beneficial effect of propofol on arterial adenosine triphosphate-sensitive K^+channel function impaired by thromboxane2009

    • Author(s)
      Haba M, Kinoshita H, Matsuda N, Azma T, Hama-Tomioka K, Hatakeyama N, Yamazaki M, Hatano Y
    • Journal Title

      Anesthesiology

      Volume: 111 Pages: 279-286

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 高血糖による生体侵襲2009

    • Author(s)
      木下浩之
    • Journal Title

      救急・集中治療 20

      Pages: 1177-1180

    • Related Report
      2009 Annual Research Report
  • [Journal Article] The beneficial effect of propofol on arterial adenosine triphosphate-sensitive K^+ channel function impaired by thromboxane2009

    • Author(s)
      Haba M, Kinoshito H, et al.
    • Journal Title

      Anesthesiology 111

      Pages: 279-286

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Isoflurane protects ATP-sensitive K^+channels from oxidativ e stress caused by high glucose in the human artery2011

    • Author(s)
      Kinoshita H, Matsuda N, Iranami H, Azma T, Yamazaki M
    • Organizer
      2011 Annual Meeting of American Society of Anesthesiologist
    • Place of Presentation
      Chicago, IL, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] 酸化ストレスが血管反応に及ぼす作用と麻酔薬2011

    • Author(s)
      木下浩之
    • Organizer
      日本麻酔科学会第58回学術集会
    • Place of Presentation
      兵庫県神戸市
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] イソフルランは高濃度ブドウ糖による酸化ストレスからヒトATP感受性カリウムチャネル機能を保護する2011

    • Author(s)
      木下浩之、松田直之、東俊晴、畠山登、伊良波浩、山崎光章
    • Organizer
      日本麻酔科学会第58回学術集会
    • Place of Presentation
      兵庫県神戸市
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Isoflurane protects human ATP-sensitive K^+channels from oxidative stress induced by high glucose2010

    • Author(s)
      Kinoshita H, Matsuda N, Hatakeyama N, Iranami H, Hatano Y
    • Organizer
      2010 Annual Meeting of American Society of Anesthesiologist
    • Place of Presentation
      San Diego, CA, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] 高濃度ブドウ糖で抑制されたヒト大網動脈ATP感受性カリウムチャネル機能に及ぼす細胞骨格制御の効果2010

    • Author(s)
      木下浩之、松田直之、東俊晴、畠山登、中畑克俊、畑埜義雄
    • Organizer
      日本麻酔科学会第57回学術集会
    • Place of Presentation
      福岡県福岡市
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Isoflurane protects human ATP-sensitive K^+ channels from oxid ative stress induced by high glucose2010

    • Author(s)
      Kinoshita H, Matsuda N, Hatakeyama N, Iranami H, Hatano Y
    • Organizer
      2010 Annual Meeting of American Society of Anesthesiologist
    • Place of Presentation
      San Diego
    • Related Report
      2010 Annual Research Report
  • [Presentation] The Role of Cytoskeleton in Vascular ATP-Sensitive K^+Channel Function Modified by High Glucose2009

    • Author(s)
      Kinoshita H, Hatakeyama N, Hatano Y
    • Organizer
      2009 Annual Meeting of American Society of Anesthesiologist
    • Place of Presentation
      New Orleans, LA
    • Related Report
      2011 Final Research Report
  • [Presentation] The Role of Cytoskeleton in Vascular ATP-Sensitive K^+ Channel Function Modified by High Glucose2009

    • Author(s)
      Hiroyuki Kinoshita, et al.
    • Organizer
      Annual Meeting of American Society of Anesthesiologist
    • Place of Presentation
      New Orleans, LA, USA
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.wakayama-med.ac.jp/med/anesthesiology/index.html

    • Related Report
      2011 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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