Characterizing pharmacodynamic interactions of anesthetics on parallel/serial neural circuit model

• Project/Area Number: 21591991
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Hyogo Medical University
• Principal Investigator: KAMINOH Yoshiroh 兵庫医科大学, 医学部, 教授 (30289061)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: 薬物相互作用 / 麻酔作用機序 / 神経ネットワーク / 相乗効果並列回路 / 薬力学 / 薬物動態 / 相乗効果 / 並列回路

Research Abstract

Producing the anesthetic state is at least a two drug process typically consisting of a hypnotic and an opioid. Models that adequately characterize pharmacodynamic drug interactions are important to understanding anesthetic behavior. We proposed the parallel/serial neural circuit model and characterized its mathematical behavior. The model predicted that the additive interaction occurred only when the mechanism of anesthetics were identical. Some combination of anesthetics showed additive, even though their potencies on molecular level were different. We showed the condition required for the clinically additive interaction using the parallel/serial circuit model.

Research Products

• [Presentation] Is the interaction of inhalation anesthetics additive (2010)
  • Author(s): Yoshiroh Kaminoh
  • Organizer: International Society for Anesthetic Pharmacology 2010
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2010-10-15
• [Presentation] Is the interaction of inhalation anesthetics additive? (2010)
  • Author(s): Yoshiroh Kaminoh
  • Organizer: International Society for Anesthetic Pharmacology
  • Place of Presentation: 米国、カリフォルニア州サンディエゴ市
  • Year and Date: 2010-10-15
• [Presentation] Parallel/series neural network model can explain anesthetic pharmacological interactions (2010)
  • Author(s): Yoshiroh Kaminoh
  • Organizer: Mechanisms of Anesthesia Conference 2010
  • Place of Presentation: Toronto, Ontario, CANADA
• [Presentation] Parallel/series neural network model can explain anesthetic pharmacological interactions. (2010)
  • Author(s): Yoshiroh Kaminoh
  • Organizer: Mechanisms of Anesthesia Conference 2010
  • Place of Presentation: カナダ、オンタリオ州トロント市