Effects of Neurosteroids on Postoperative Pain

Research Project

Project/Area Number	21591997
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Anesthesiology/Resuscitation studies
Research Institution	University of Tsukuba
Principal Investigator	FUKUDA TAEKO 筑波大学, 医学医療系, 講師 (40228911)
Co-Investigator(Kenkyū-buntansha)	HISANO Setsuji 筑波大学, 医学医療系, 教授 (70136216)
Project Period (FY)	2009-04-01 – 2014-03-31
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000) Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000) Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000) Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	ニューロステロイド / 術後痛 / 動物モデル
Research Abstract	Effects of allopregnanolone, which is a neurosteroid, were investigated in Brennan's postsurgical rat pain model. Mechanical allodynia persisted for 7 days after surgery in finasteride, a inhibitor of allopregnanolone synthase, group. Alopregnanolone low dose (0.16 mg/kg ip) group, not high dose (1.6 mg/kg ip) group, showed higher mechanical pain threshold than that of control group after surgery. The results suggest that allopregnanolone inhibits development of hypersensitivity after surgery on multiple mechanisms, because it was not dose-dependent. Furthermore, allopregnanolone increased anti-allodynic effects of gabapentine, not indomethacin and acetoaminophen.