Effects of Neurosteroids on Postoperative Pain
Project/Area Number |
21591997
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Anesthesiology/Resuscitation studies
|
Research Institution | University of Tsukuba |
Principal Investigator |
FUKUDA TAEKO 筑波大学, 医学医療系, 講師 (40228911)
|
Co-Investigator(Kenkyū-buntansha) |
HISANO Setsuji 筑波大学, 医学医療系, 教授 (70136216)
|
Project Period (FY) |
2009-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | ニューロステロイド / 術後痛 / 動物モデル |
Research Abstract |
Effects of allopregnanolone, which is a neurosteroid, were investigated in Brennan's postsurgical rat pain model. Mechanical allodynia persisted for 7 days after surgery in finasteride, a inhibitor of allopregnanolone synthase, group. Alopregnanolone low dose (0.16 mg/kg ip) group, not high dose (1.6 mg/kg ip) group, showed higher mechanical pain threshold than that of control group after surgery. The results suggest that allopregnanolone inhibits development of hypersensitivity after surgery on multiple mechanisms, because it was not dose-dependent. Furthermore, allopregnanolone increased anti-allodynic effects of gabapentine, not indomethacin and acetoaminophen.
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Report
(6 results)
Research Products
(3 results)