Effect of the new inhalation anesthetic Desflurane on airway hyperreactivity

• Project/Area Number: 21592019
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Sapporo Medical University
• Principal Investigator: YAMAKAGE Michiaki 札幌医科大学, 医学部, 教授 (70285005)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 気道平滑筋 / 気道過敏性 / 吸入麻酔薬 / タキキニン / ロリプラム / セボフルラン / 気道過敏症 / デスフルラン / 気道抵抗 / 全身麻酔 / PDE3阻害薬 / ミルリノン / オルプリノン / テオフィリン

Research Abstract

This study reveals the mechanism by which the new inhalation anesthetic, desflurane, affects airway heperreactivity. Desflurane relaxed the smooth muscle in ovalbumin-sensitized guinea pigs in vitro, while, conversely, increasing airway resistance in a dose dependent manner in in vivo experiments. These effects could partly be explained by desflurane activation of the tachykinin pathway. This knowledge will contribute to the anesthetic management of patients with hyperresponsive airways.

Research Products

• [Journal Article] Synergic bronchodilator effects of a phosphodiesterase 3 olprinone with a volatile anaesthetic sevoflurane in ovalbumin-sensitized guinea pigs (2011)
  • Author(s): Zhou J, Iwasaki S, Watanebe A, Yamakage M
  • Journal Title: Eur J Anaesthesiol Volume: 28 Issue: 7 Pages: 519-24
  • DOI: 10.1097/eja.0b013e3283463f4a
  • Peer Reviewed
• [Journal Article] Pralidoxime inhibits paraoxon-induced depression of rocuronium-neuromuscular block in a time-dependent fashion (2011)
  • Author(s): Narimatsu E, Niiya T, Takahashi K, Yamauchi M, Yamakage M
  • Journal Title: Am J Emerg Med
  • URL: http://dx.doi.org/10.1016/j.ajem.2011.06.013
  • Peer Reviewed
• [Journal Article] Desflurane induced airway contraction mainly by acting transient receptor potential A1 of sensory C-fibers (2010)
  • Author(s): Sato J-I, Yamakage M
  • Journal Title: J Anesth Volume: 23 Issue: 4 Pages: 620-3
  • DOI: 10.1007/s00540-009-0786-8
  • Peer Reviewed
• [Journal Article] Low-dose continuous infusion of landiolol can reduce adrenergic response during tracheal intubation in elderly patients with cardiovascular disease (2010)
  • Author(s): Hirata N, Miyashita R, Watanabe A, Yamakage M
  • Journal Title: J Anesth Volume: 24 Issue: 5 Pages: 786-8
  • DOI: 10.1007/s00540-010-0975-5
  • NAID: 10027740959
  • Peer Reviewed
• [Journal Article] Desflurane induces airway contraction mainly by activating transient… (2010)
  • Author(s): Satoh J-I, et al.
  • Journal Title: J Anesth Volume: 23 Pages: 620-623
  • Peer Reviewed
• [Journal Article] Low-dose continuous infusion of landiolol can reduce adrenergic… (2010)
  • Author(s): Hirata N, et al.
  • Journal Title: J Anesth Volume: 24 Pages: 786-788
  • Peer Reviewed
• [Journal Article] Effects of atropine and pralidoxime on neuronal actions of paraoxon… (2010)
  • Author(s): Narimatsu E, et al.
  • Journal Title: Neurosci Res Volume: 68 Pages: 276-284
  • Peer Reviewed
• [Journal Article] Desflurane but not sevoflurane can increase lung resistance via tachykinin pathways (2009)
  • Author(s): Satoh J-I, Yamakage M, Kobayashi T, Tohse N, Watanabe H, Namiki A
  • Journal Title: Br J Anaesth Volume: 102 Issue: 5 Pages: 704-13
  • DOI: 10.1093/bja/aep041
  • Peer Reviewed
• [Journal Article] Beta-1 selective adrenergic antagonist landiolol and esmolol..... (2009)
  • Author(s): Yamakage M, et al.
  • Journal Title: Heart Lung 38 Pages: 48-55
  • Peer Reviewed
• [Journal Article] Performance of four carbon dioxide absorbents in.... (2009)
  • Author(s): Yamakage M, et al.
  • Journal Title: Anaesthesia 64 Pages: 287-292
  • Peer Reviewed
• [Journal Article] Desflurane but not sevoflurane can increase lung.... (2009)
  • Author(s): Satoh J-I, et al.
  • Journal Title: Br J Anaesth 102 Pages: 704-713
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): Namiki A, Yamakage M
  • Journal Title: Miller's Anesthesia(Elsevier Inc.) Pages: 60-61
• [Presentation] Synergic bronchodilator effects of the PDE4 inhibitor rolipram with the volatile anesthetic sevoflurane in guinea pigs (2011)
  • Author(s): Zhou J, Iwasaki S, Yamauchi M, Yamakage M
  • Organizer: The annual meeting of American Society of Anesthesiologists
  • Place of Presentation: Chicago, USA
• [Presentation] Different volatile anesthetics have different bronchodilator effects in Ovalbumin-sensitized guinea pigs (2011)
  • Author(s): Zhou J, Iwasaki S, Yamauchi M, Yamakage M
  • Organizer: The annual meeting of American Society of Anesthesiologists
  • Place of Presentation: Chicago, USA
• [Presentation] Synergistic Bronchodilator Effects of the PDE4 Inhibitor Rolipram with the Volatile Anesthetic Sevoflurane in Guinea Pigs (2011)
  • Author(s): Yamakage M, et al
  • Organizer: The annual meeting of ASA
  • Place of Presentation: シカゴ,米国
• [Presentation] Different Volatile Anesthetics Have Different Brochodilator Effects in Ovalbumin-sensitized Guinea Pigs (2011)
  • Author(s): Yamakage M, et al
  • Organizer: The annual meeting of ASA
  • Place of Presentation: シカゴ,米国
• [Presentation] 禁煙・麻酔薬の気管支平滑筋に及ぼす影響 (2010)
  • Author(s): 山蔭道明
  • Organizer: 日本麻酔科学会第57回学術大会
  • Place of Presentation: 福岡
  • Year and Date: 2010-06-03
• [Presentation] 喫煙・麻酔薬の気管支平滑筋に及ぼす影響 (2010)
  • Author(s): 山蔭道明
  • Organizer: 日本麻酔科学会第57回学術大会
  • Place of Presentation: 福岡
  • Year and Date: 2010-06-03
• [Presentation] Synergic bronchodilator effects of PDE3 inhibitors with sevoflurane in asthmatic guinea pigs (2010)
  • Author(s): Zhou J, Iwasaki S, Yamakage M
  • Organizer: The annual meeting of American Society of Anesthesiologists
  • Place of Presentation: San Diego, USA
• [Presentation] Desflurane induces airway contraction by activating.... (2009)
  • Author(s): Yamakage M,, et al.
  • Organizer: The annual meeting of ASA
  • Place of Presentation: ニューオーリンズ, 米国
  • Year and Date: 2009-10-17
• [Presentation] Desflurane but not sevoflurane can increase lung resistance via tachykinin pathways (2009)
  • Author(s): Yamakage M, Satoh J-I
  • Organizer: The annual meeting of American Society of Anesthesiologists
  • Place of Presentation: New Orleans, USA
• [Presentation] Desflurane induces airway contraction by activating transient receptor potential A1 of C-fibers (2009)
  • Author(s): Yamakage M, Satoh J-I, Kobayashi T, Watanabe H
  • Organizer: The annual meeting of American Society of Anesthesiologists
  • Place of Presentation: New Orleans, USA
• [Book] 「周術期の体温管理」For Professional Anesthesiologists (2011)
  • Author(s): 山蔭道明
  • Publisher: 克誠堂出版
• [Book] PCA患者自己調節鎮痛法 (2011)
  • Author(s): 山蔭道明
  • Publisher: 克誠堂出版
• [Book] セボフルランの呼吸器系に及ぼす影響-セボフルラン-基礎を知れば臨床がわかる (2010)
  • Author(s): 山蔭道明
  • Publisher: メディカル・サイエンス・インターナショナル
• [Book] XII.代謝の生理学-第10章:基礎的生理学とモニタリング-周術期管理チームテキスト (2010)
  • Author(s): 山内正憲, 山蔭道明
  • Publisher: メディカル・サイエンス・インターナショナル
• [Book] XIII.体温測定-第10章:基礎的生理学とモニタリング-周術期管理チームテキスト (2010)
  • Author(s): 山内正憲, 山蔭道明
  • Publisher: メディカル・サイエンス・インターナショナル
• [Book] セボフルラン-基礎を知れば臨床がわかる (2010)
  • Author(s): 山蔭道明
  • Total Pages: 18
  • Publisher: メディカル・サイエンス・インターナショナル
• [Remarks]
  • URL: http://www.sapmed.ac.jp/masui
• [Remarks]
  • URL: http://www.sapmd.ac.jp/masui
• [Remarks]
  • URL: http://web.sapmed.ac.jp/masui
• [Remarks]
  • URL: http://web.sapmed.ac.jp/masui