| Project/Area Number |
21592024
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OSHIO Koichi 慶應義塾大学, 医学部, 講師 (90185588)
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| Co-Investigator(Renkei-kenkyūsha) |
ABE Koji 慶應義塾大学, 医学部, 助教 (20445224)
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| Research Collaborator |
YAMABE Eiko
MIYAZAKI Kaori
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 複合性局所疼痛症候 / 慢性疼痛動物モデル / 拡散強調MRI / 見かけの拡散係数 / 拡散強調MRスペクトロスコピー / T2値 / 末梢浮腫 / 以上疼痛 / 複合性局所疼痛症候群 / 異常疼痛 / 複合性局所疼痛症侯群 / 拡散強調スペクトロスコピー / みかけの拡散係数 |
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| Research Abstract |
We could detect the extremely early edematous changes in the affected skeletal muscle in the neuropathic pain animal model and in the denervated muscle using diffusion MRI. T2 ratios increased gradually with a peak at three weeks in CRPS model and 4 weeks in denervated model. ADC ratios jumped up at one day after the surgery and began to decrease at one week in both models, while absolute ratio is much higher in denervated model. AQ4 monoclonal antibody staining indicated that slightly higher incidence of AQ4 in denervated model. Diffusion MRI can be a useful tool to detect the early edematous change of CRPS affected limbs.
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