Novel oncolytic HSV-1 for treatment of slowly-growing tumors such as prostate carcinoma or renal cell carcinoma
Project/Area Number |
21592033
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Urology
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Research Institution | The University of Tokyo |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
NOMIYA Akira 東京大学, 医学部附属病院, 助教 (30372379)
武内 巧 東京大学, 医学部附属病院, 准教授 (90167487)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 前立腺癌 / 腎癌 / ウイルス療法 / 遺伝子治療 / 癌 |
Research Abstract |
We constructed novel oncolytic HSV-1 using G47Δ's structure, with mutations in the ICP6, g34. 5, and a47 genes, as the basic backbone. The new virus, T-hTERT, contains a functioning ICP6 gene(encoding the large subunit of viral RR) controlled by tumor specific promoter. The in vitro replication capability of T-hTERT was higher than the control virus T-01, with an ICP6 deletion, in some and comparable to T-01 in other cell lines tested. In athymic mice bearing subcutaneous tumors, intraneoplastic injections with T-hTERT demonstrated higher efficacy than T-01 for renal cell carcinoma or prostate cancer.
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] Association between lower urinary tract symptoms and sexual dysfunction assessed using the core lower urinary tract symptom score and International index of erectile function-5 questionnaires2012
Author(s)
Nakamura M, Fujimura T, Nagata M, Hosoda C, Suzuki M, Fukuhara H, Enomoto Y, Nishimatsu H, Kume H, Igawa Y, Homma Y
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Journal Title
Aging Male
Volume: (in press)
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[Journal Article] Management trends, angioembolization performance and multiorgan injury indicators of renal trauma from Japanese administrative claims database2012
Author(s)
Sugihara T, Yasunaga H, Horiguchi H, Nishimatsu H, Fukuhara H, Enomoto Y, Kume H, Ohe K, Matsuda S, Homma Y
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Journal Title
Int J Urol
Volume: (in press)
NAID
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[Journal Article] Assessment of lower urinary tract symptoms in men by international prostate symptom score and core lower urinary tract symptom score2011
Author(s)
Fujimura T, Kume H, Nishimatsu H, Sugihara T, Nomiya A, Tsurumaki Y, Miyazaki H, Suzuki M, Fukuhara H, Enomoto Y, Homma Y
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Journal Title
BJU Int
Volume: (in press)
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[Journal Article] Association of rs6983561 Polymorphism at 8q24 With Prostate Cancer Mortality in a Japanese Population2011
Author(s)
Suzuki M, Liu M, Kurosaki T, Suzuki M, Arai T, Sawabe M, Kasuya Y, Kato M, Fujimura T, Fukuhara H, Enomoto Y, Nishimatsu H, Ishikawa A, Kume H, Homma Y, Kitamura T
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Journal Title
Clin Genitourin Cancer
Volume: 9
Pages: 46-52
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[Journal Article] Aberrations of a cell adhesion molecule CADM4 in renal clear cell carcinoma2011
Author(s)
Nagata M, Sakurai-Yageta M, Yamada D, Goto A, Ito A, Fukuhara H, Kume H, Morikawa T, Fukayama M, Homma Y, Murakami Y
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Journal Title
Int J Cancer
Volume: 130
Pages: 1329-1337
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[Journal Article] Prognostic Factors for Renal Cell Carcinoma With Bone Metastasis : Who Are the Long-Term Survivors?2011
Author(s)
Kume H, Kakutani S, Yamada Y, Shinohara M, Tominaga T, Suzuki M, Fujimura T, Fukuhara H, Enomoto Y, Nishimatsu H, Homma Y
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Journal Title
J Urol
Volume: 185
Pages: 1611-1614
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[Journal Article] Final report on low-dose estramustine phosphate(EMP) monotherapy and very low-dose EMP therapy combined with LH-RH agonist for previously untreated advanced prostate cancer2010
Author(s)
Kitamura T, Suzuki M, Nishimatsu H, Kurosaki T, Enomoto Y, Fukuhara H, Kume H, Takeuchi T, Miao L, Jiangang H, Xiaoqiang L
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Journal Title
Related Report
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[Journal Article] Identification of DBC1 as a transcriptional repressor for BRCA12010
Author(s)
Hiraike H, Wada-Hiraike O, Nakagawa S, Koyama S, Miyamoto Y, Sone K, Tanikawa M, Tsuruga T, Nagasaka K, Matsumoto Y, Oda K, Shoji K, Fukuhara H, Saji S, Nakagawa K, Kato S, Yano T, Taketani Y
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Journal Title
Br JCancer
Volume: 102
Pages: 1061-1064
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[Journal Article] Repression of estrogen receptor beta function by putative tumor suppressor DBC12010
Author(s)
Koyama S, Wada-Hiraike O, NakagawaS, Tanikawa M, Hiraike H, Miyamoto Y, Sone K, Oda K, Fukuhara H, Nakagawa K, Kato S, Yano T, Taketani Y
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Journal Title
Biochem Biophys Res Commun
Volume: 392
Pages: 357-362
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