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Identification and translational research of transmenbrane and secretary proteins in prostate cancer

Research Project

Project/Area Number 21592046
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionHiroshima University

Principal Investigator

MATSUBARA Akio  広島大学, 大学院・医歯薬学総合研究科, 教授 (10239064)

Co-Investigator(Kenkyū-buntansha) YASUI Wataru  広島大学, 大学院・医歯薬学総合研究科, 教授 (40191118)
TEISHIMA Jun  広島大学, 大学院・医歯薬学総合研究科, 講師 (20397962)
INOUE Shogo  広島大学, 病院, 病院助教 (90457177)
HAYASHI Tetsutaro  広島大学, 大学院・医歯薬学総合研究科, 助教 (60612835)
大原 慎也  広島大学, 病院, 助教 (70444693)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
KeywordsCAST法 / 分泌蛋白 / 前立腺癌 / 膜蛋白
Research Abstract

We identified candidate genes that encode transmembrane proteins present in PCa from the screening of Escherichia coli ampicillin secretion trap(CAST) libraries. Further investigations reveled that CDON and NBL1 were expressed much more highly in PCa, suggesting that these molecules have a high potential as a therapeutic target for PCa. Furthermore, we conclude that DSC2 is a useful immunohistochemical marker for separation of squamous differentiation of urothelial carcinoma.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (23 results)

All 2011 2010 2009

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (21 results)

  • [Journal Article] Identification of transmembraneprotein in prostate cancer by the Escherichiacoli ampicillin secretion trap : expressionof CDON is involved in tumor cell growth andinvasion2011

    • Author(s)
      Hayashi T, Ohara S, Teishima J, MatsubaraA, Yasui W
    • Journal Title

      Pathobiology

      Volume: 78 Issue: 5 Pages: 277-284

    • DOI

      10.1159/000329588

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Desmocollin 2 is a newimmunohistochemical marker indicative ofsquamous differentiation in urothelialcarcinoma2011

    • Author(s)
      Hayashi T, Ohara S, Teishima J, MatsubaraA, Yasui W
    • Journal Title

      Histopathology

      Volume: 59 Issue: 4 Pages: 710-721

    • DOI

      10.1111/j.1365-2559.2011.03988.x

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Presentation] The search for novel genesencoding secreted and transmembrane proteinsin prostate cancer by the Escherichia coliampicillin secretion trap2011

    • Author(s)
      HayashiT, OharaS, TeishimaJ, MatsubaraA, Yasui W
    • Organizer
      第63回日本泌尿器泌尿器科学西日本総会
    • Place of Presentation
      久留米市
    • Year and Date
      2011-11-12
    • Related Report
      2011 Final Research Report
  • [Presentation] The search for novel genes encoding secreted and transmembrane proteins in prostate cancer by the Escherichia coli ampicillin secretion trap2011

    • Author(s)
      Hayashi T, Ohara S, Teishima J, Matsubara A, Yasui W
    • Organizer
      第63回日本泌尿器泌尿器科学西日本総会
    • Place of Presentation
      久留米
    • Year and Date
      2011-11-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] CAST法を用いた前立腺癌の分泌蛋白の検討:NBL1の発現は前立腺癌に特異的である2011

    • Author(s)
      林哲太郎, 大原慎也, 亭島淳, 安井弥, 松原昭郎
    • Place of Presentation
      名古屋市
    • Year and Date
      2011-10-03
    • Related Report
      2011 Final Research Report
  • [Presentation] CAST法を用いた前立腺癌の分泌蛋白の検討:NBL1の発現は前立腺癌に特異的である2011

    • Author(s)
      林哲太郎、大原慎也、亭島淳、安井弥、松原昭郎
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] DSC2 is a new immunohistochemical marker indicative of squamous cell carcinoma component in urinary bladder cancer and a value of prognostic factor2011

    • Author(s)
      Hayashi T, Ohara S, Teishima J, Matsubara A, Yasui W
    • Organizer
      The 2011 Annual Meeting of the American Urological Association
    • Place of Presentation
      Washington D.C.(USA)
    • Year and Date
      2011-05-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Identification of transmembraneprotein in prostate cancer by the Escherichiacoli ampicillin secretion trap : expressionof CDON is involved in tumor cell growth andinvasion2011

    • Author(s)
      Hayashi T, Ohara S, Teishima J, MatsubaraA, Yasui W
    • Organizer
      The 2011 Annual Meeting of theAmerican Urological Association
    • Place of Presentation
      Washington D. C. USA
    • Year and Date
      2011-05-15
    • Related Report
      2011 Final Research Report
  • [Presentation] DSC2 is a new immunohistochemicalmarker indicative of squamous cell carcinomacomponent in urinary bladder cancer and avalue of prognostic factor2011

    • Author(s)
      Hayashi T, Ohara S, Teishima J, Matsubara A, Yasui W
    • Organizer
      The 2011 AnnualMeeting of the American UrologicalAssociation
    • Place of Presentation
      Washington D. C. USA
    • Year and Date
      2011-05-15
    • Related Report
      2011 Final Research Report
  • [Presentation] Identification of transmembrane protein in prostate cancer by the Escherichia coli ampicillin secretion trap : expression of CDON is involved in tumor cell growth and invasion2011

    • Author(s)
      Hayashi T, Ohara S, Teishima J, Matsubara A, Yasui W
    • Organizer
      The 2011 Annual Meeting of the American Urological Association
    • Place of Presentation
      Washington D.C.(USA)
    • Year and Date
      2011-05-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] 腎細胞癌におけるTSPAN8の発現の意義2011

    • Author(s)
      林哲太郎, 大原慎也, 松原昭郎, 安井弥
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜市
    • Year and Date
      2011-04-30
    • Related Report
      2011 Final Research Report
  • [Presentation] 腎細胞癌におけるTSPAN8の発現の意義2011

    • Author(s)
      林哲太郎、大原慎也、松原昭郎、安井弥
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2011-04-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] CAST法を用いた前立腺癌の新規膜蛋白・分泌蛋白の解析:前立腺癌におけるTMEM50Bの発現の意義2011

    • Author(s)
      林哲太郎, 大原慎也, 松原昭郎, 安井弥
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜市
    • Year and Date
      2011-04-29
    • Related Report
      2011 Final Research Report
  • [Presentation] CAST法を用いた前立腺癌の新規膜蛋白・分泌蛋白の解析:前立腺癌におけるTMEM50Bの発現の意義2011

    • Author(s)
      林哲太郎、大原慎也、松原昭郎、安井弥
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2011-04-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] 扁平上皮癌成分を伴う膀胱癌の新規診断マーカーDSC2とその予後因子としての意義2011

    • Author(s)
      林哲太郎, 大原慎也亭島淳, 松原昭郎, 安井弥
    • Organizer
      第99回日本泌尿器科学会総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2011-04-24
    • Related Report
      2011 Final Research Report
  • [Presentation] 扁平上皮癌成分を伴う膀胱癌の新規診断マーカーDSC2とその予後因子としての意義2011

    • Author(s)
      林哲太郎, 大原慎也, 亭島淳, 松原昭郎, 安井弥
    • Organizer
      第99回日本泌尿器科学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-04-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] CAST法を用いた前立腺癌の新規膜蛋白・分泌蛋白の解析2011

    • Author(s)
      林哲太郎、大原慎也、亭島淳、安井弥、松原昭郎
    • Organizer
      第20回泌尿器科分子・細胞研究会
    • Place of Presentation
      三重
    • Year and Date
      2011-03-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] Analyses of novel genes encoding secreted and transmembrane proteins identified by the Escherichia coli ampicillin secretion trap : expression of CDON is involved in tumor cell growth and invasion.2011

    • Author(s)
      Hayashi T, Ohara S, Teishima J, Matsubara A, Yasui W
    • Organizer
      Advancements in Urology 2011 an AUA/JUA Symposium
    • Place of Presentation
      Hawaii (USA)
    • Year and Date
      2011-02-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] 前立腺癌細胞株において発現している分泌/膜貫通蛋白質のCAST法を用いた解析2010

    • Author(s)
      林哲太郎、大原慎也、松原昭郎、安井弥
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 分泌/膜貫通蛋白質のCAST法を用いた解析:前立腺癌におけるCDONの発現と増殖・浸潤との関連2010

    • Author(s)
      林哲太郎, 大原慎也, 松原昭郎, 安井弥
    • Organizer
      第19回日本がん転移学会学術集会・総会
    • Place of Presentation
      金沢
    • Year and Date
      2010-06-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Analyses of novel genes encoding secreted and transmembrane proteins identified by CAST method : CDON is highly expressed in prostate cancer.2010

    • Author(s)
      Hayashi T, Ohara S, Teishima J, Matsubara A, Yasui W
    • Organizer
      The 101st Annual Meeting of the American Association for Cancer Research
    • Place of Presentation
      Washington D.C.(USA)
    • Year and Date
      2010-04-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Search for secreted and transmembrane protein using CAST : CDON is highly expressed in prostate cancer2009

    • Author(s)
      林哲太郎, 大原慎也, 松原昭郎, 安井弥
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] CAST法を用いた前立腺癌の分泌・膜蛋白の網羅的遺伝子解析2009

    • Author(s)
      林哲太郎, 大原慎也, 松原昭郎, 安井弥
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      京都
    • Year and Date
      2009-05-02
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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