Genetic variations in patients with clear cell renal cancer

• Project/Area Number: 21592047
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Urology
• Research Institution: Yamaguchi University
• Principal Investigator: SAKANO Shigeru 山口大学, 医学部附属病院, 講師 (60363107)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 腎癌 / 遺伝子多型 / コピー数多型 / 予後

Research Abstract

In clear cell renal cell carcinoma(CCRCC) patients, MTHFR and RASSF1A genotypes and haplotypes might be useful as prognostic factors. Furthermore, these findings might contribute to the understanding of the mechanisms underlying CCRCC progression. We have found copy number variations that are potentially involved in the risk of CCRCC development.

Research Products

• [Journal Article] Association of RASSF1A genotype and haplotype with the progression of clear cell renal cell carcinoma in Japanese patients (2012)
  • Author(s): Yoshihisa Kawai, Shigeru Sakano, Naoko Okayama, Yutaka Suehiro, Hideyasu Matsuyama, Yuji Hinoda
  • Journal Title: BJU International Volume: In press
  • Peer Reviewed
• [Journal Article] Association of RASSF1A genotype and haplotype with the progression of clear cell renal cell carcinoma in Japanese patients (2012)
  • Author(s): Yoshihisa Kawai
  • Journal Title: BJU International Volume: (in press) Issue: 7 Pages: 1070-1075
  • DOI: 10.1111/j.1464-410x.2012.11143.x
  • Peer Reviewed
• [Journal Article] Gender-specific association of methylenetetrahydrofolate reductase genotype and haplotype with the aggressiveness and prognosis of clear cell renal cell carcinomain Japanese patients (2010)
  • Author(s): Shigeru Sakano, Yuji Hinoda, Naoko Okayama, Yoshihisa Kawai, Hideaki Ito, Kazuhiro Nagao, Takahiko Hara, Hideyasu Matsuyama
  • Journal Title: BJU International Volume: 106 Pages: 424-430
  • Peer Reviewed
• [Journal Article] Methylation level of the RASSF1A promoter is an independent prognostic factor for clear-cell renal cell carcinoma (2010)
  • Author(s): Yoshihisa Kawai, Shigeru Sakano, Yutaka Suehiro, Toshiyuki Okada, Yoshihito Korenaga, Takahiko Hara, Katsusuke Naito, Hideyasu Matsuyama, Yuji Hinoda
  • Journal Title: Annals of Oncology Volume: 21 Pages: 1612-1617
  • Peer Reviewed
• [Journal Article] Gender-specific association of methylenetetrahydrofolate reductase genotype and haplotype with the aggressiveness and prognosis of clear cell renal cell carcinoma in Japanese patients (2010)
  • Author(s): Shigeru Sakano
  • Journal Title: BJU International Volume: 106 Pages: 424-430
  • Peer Reviewed
• [Presentation] Methylenetetrahydrofolatereductase genotype and haplotype may beassociated with the aggressiveness andprognosis of clear cell renal cellcarcinoma (2011)
  • Author(s): Shigeru Sakano, Yuji Hinoda, NaokoOkayama, Yoshihisa Kawai, Jun Nishijima, Yoshihiro Miyachika, Hiroaki Matsumoto, Kazuhiro Nagao, Takahiko Hara, HideyasuMatsuyama
  • Organizer: The 32nd Congress of the Societe Internationale d' Urologie
  • Place of Presentation: Berlin, Germany
  • Year and Date: 2011-10-17
• [Presentation] Methylenetetrahydrofolate Reductase Genotype and Haplotype May Be Associated with the Aggressiveness and Prognosis of Clear Cell Renal Cell Carcinoma (2011)
  • Author(s): Shigeru Sakano
  • Organizer: The 32nd Congress of the Societe Internationale d'Urologie
  • Place of Presentation: Berlin, Germany
  • Year and Date: 2011-10-17
• [Presentation] Methylenetetrahydrofolate reductase genotype or haplotype and the prognosis of clear cell renal cell carcinoma (2009)
  • Author(s): Shigeru Sakano, Yuji Hinoda, Naoko Okayama, Yoshihisa Kawai, Hideaki Ito, Satoshi Eguchi, Yoshihiro Miyachika, Taku Misumi, Tomohiko Hara, Kazuhiro Nagao, Takahiko Hara, Katsusuke Naito, Hideyasu Matsuyama
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜市パシフィコ横浜
  • Year and Date: 2009-10-02
• [Presentation] Methylenetetrahydrofolate reductase genotype or haplotype and the prognosis of clear cell renal cell carcinoma (2009)
  • Author(s): Shigeru Sakano
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 神奈川県・パシフィコ横浜
  • Year and Date: 2009-10-02