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Establishment of magnetic field induced interstitial hyperthermic therapy for specific metastatic lesion of prostate cancer using antibody conjugated magnetic nano-partilce

Research Project

Project/Area Number 21592055
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionNagoya City University

Principal Investigator

KAWAI Noriyasu  名古屋市立大学, 大学院・医学研究科, 講師 (20254279)

Co-Investigator(Kenkyū-buntansha) TOZAWA Keiichi  名古屋市立大学, 大学院・医学研究科, 准教授 (40264733)
HASHIMOTO Yoshihiro  名古屋市立大学, 大学院・医学研究科, 研究員 (40244561)
ANDO Ryosuke  名古屋市立大学, 大学院・医学研究科, 研究員 (30381867)
KOHRI Kenjiro  名古屋市立大学, 大学院・医学研究科, 教授 (30122047)
FUKUTA Katsuhiro  名古屋市立大学, 大学院・医学研究科, 研究員 (30468251)
IKEGAMI Yosuke  名古屋市立大学, 大学院・医学研究科, 研究員 (40381868)
小林 猛  中部大学, 応用生物学部, 教授 (10043324)
安藤 亮介  名古屋市立大学, 大学院・医学研究科, 研究員 (00529175)
Co-Investigator(Renkei-kenkyūsha) KOBAYASHI Takeshi  中部大学, 応用生物学部, 教授 (10043324)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords前立腺癌骨転移 / 磁場誘導組織内加温法 / 抗体結合型磁性ナノ粒子 / 温熱治療 / 磁性ナノ粒子 / 前立腺癌 / ナノテクノロジー / 癌転移巣治療 / 転移巣治療 / 磁場誘導加温法
Research Abstract

(1) Bone invasion model : Interstitial hyperthermia with magnetite demonstrated suppression of bone invasion of prostate cancer.
(2) Prostate membrane specific antigen : The character of anti PMSA antibody was examined. Immunohistochemistry reviled moderate adhesion of anti PMSA antigen to prostate cancer cells.
(3) Manufacturing of anti PMSA antibody-conjugated magnetie : The success rate was low in the making of the AML using PMSA. We should review the form of the magnetite nanoparticle.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (8 results)

All 2011 2010

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (4 results) Book (1 results)

  • [Journal Article] Preoperative Prediction of Neurovascular Bundle Involvement of Localized Prostate Cancer by Combined T2 and Diffusion-weighted Imaging of Magnetic Resonance Imaging, Number of Positive Biopsy Cores, and Gleason Score2011

    • Author(s)
      Naiki T, Okamura T, Nagata D, Mori Y, Kawai N, Ogawa K, Akita H, Hashimoto Y, Tozawa K, Kohri K
    • Journal Title

      Asian Pac J Cancer Prev

      Volume: 12 Pages: 909-13

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Single monthly bacillus Calmette-Guerin intravesical instillation is effective maintenance therapy to prevent recurrence in Japanese patients with non-muscle-invasive bladder cancer2011

    • Author(s)
      Okamura Takehiko, Akita Hidetoshi, Ando Ryosuke, Ikegami Yosuke, Naiki Taku, Kawai Noriyasu, Tozawa Keiichi, Kohri Kenjiro
    • Journal Title

      International Journal of Clinical Oncology

      Volume: 17(5) Issue: 5 Pages: 477-81

    • DOI

      10.1007/s10147-011-0314-3

    • NAID

      10031144335

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Targeted hyperthermia using magnetite cationic liposomes and an alternating magnetic field in a mouse osteosarcoma model2010

    • Author(s)
      Shido Y, Nishida Y. Suzuki Y, Kobayashi T, Ishiguro N
    • Journal Title

      J Bone Joint Surg Br

      Volume: 92 Pages: 580-585

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] 骨転移に対する温熱療法の基礎2011

    • Author(s)
      河合憲康
    • Organizer
      第99回日本泌尿器科学会総会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2011-04-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] 前立腺癌に対する強度変調放射線治療(IMRT)における内分泌療法併用の意義2011

    • Author(s)
      河合憲康、小林大地、内木拓、山田健司、安藤亮介、福田勝洋、池上要介、金本一洋、秋田英俊、岡村武彦、戸澤啓一、芝本雄太、郡健二郎
    • Organizer
      第49回日本癌治療学会学術集会
    • Place of Presentation
      名古屋市
    • Related Report
      2011 Final Research Report
  • [Presentation] 前立腺癌骨転移巣に対する温熱治療に向けた基礎研究:ラット前立腺癌大腿骨浸潤モデルの開発2011

    • Author(s)
      河合憲康、小林大地、佐藤慎也、小林猛、内木拓、成山泰道、橋本良博、戸澤啓一、佐々木昌一、林祐太郎、白井智之、郡健二郎
    • Organizer
      第99回日本泌尿器科学会総会
    • Place of Presentation
      名古屋市
    • Related Report
      2011 Final Research Report
  • [Presentation] Heat therapy with magnetic cationic liposome might be more useful for treatment of prostate cancer metastatic lesion than docetaxel2010

    • Author(s)
      Daichi Kobayashi
    • Organizer
      American Urological Association Annual meeting 2010
    • Place of Presentation
      MOSCONE CENTER, San Francisco, USA
    • Year and Date
      2010-05-19
    • Related Report
      2010 Annual Research Report
  • [Book] 泌尿器科レジデントマニュアル(監修郡健二郎、編集佐々木昌一、戸澤啓一、丸山哲史)2011

    • Author(s)
      河合憲康
    • Total Pages
      388
    • Publisher
      医学書院
    • Related Report
      2011 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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