A study on changes of microcirculation of the bladder wall caused by bladder outlet obstruction and effects of alpha adrenoceptor antagonists on impaired bladder microcirculation

• Project/Area Number: 21592070
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Urology
• Research Institution: Nagoya University
• Principal Investigator: GOTOH Momokazu 名古屋大学, 大学院・医学系研究科, 教授 (10186900)
• Co-Investigator(Kenkyū-buntansha): YAMAMOTO Yokunori 名古屋大学, 医学部附属病院, 講師 (20182636)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 下部尿路閉塞 / 膀胱機能障害 / 膀胱微小循環 / 膀胱血流 / 交感神経α1遮断薬 / 膀胱虚血再灌流 / 膀胱過伸展 / 前立腺肥大症 / 交感神経α遮断薬 / 膀胱虚血再潅流 / 膀胱虚血再灌流障害 / 膀胱虚血

Research Abstract

A bladder over-distension model, an ischemia-reperfusion model and a bladder outlet obstruction(BOO) model were created in rats, and microcirculation of the bladder wall was evaluated in those model rats using a pencil lens charge-coupled device microscopy system. In addition, the effect of sympathetic alpha-1 adrenoceptor(AR) antagonists on bladder microcirculation was assessed. From the results of the present study, it is suggested that bladder dysfunction occurs by an impairment of blood flow and ischemia-reperfusion injury in bladder outlet obstruction due to benign prostatic hyperplasia. Sympathetic alpha-1A AR antagonist will improve the bladder function by protecting the impairment of blood flow and ischemia-reperfusion injury.

Research Products

• [Journal Article] Effect of tamsulosin on bladder microcirculation in a rat ischemia-reperfusion model (2011)
  • Author(s): Mizuno H, Yamamoto T, Okutsu H, Ohtake A, Sasamoto M, Funahashi Y, Kato M, Hattori R, Gotoh M.
  • Journal Title: Urology Volume: 76
  • Peer Reviewed
• [Journal Article] Effect of tamsulosin on bladder microcirculation in a ratischemia-reperfusion model, evaluated by pencil lens charge-coupled device microscopy system (2011)
  • Author(s): Mizuno H, Yamamoto T, Okutsu H, Ohtake A, Sasamoto M, Funahashi Y, Kato M, Hattori R, Gotoh M
  • Journal Title: Urology Volume: 76
  • Peer Reviewed
• [Journal Article] Effect of tamsulosin on bladder microcirculation in a rat ischemia-reperfusion model, evaluated by pencil lens charge-coupled device microscopy system. (2010)
  • Author(s): Mizuno H, Okutsu H, Ohtake A, Sasamata M, Matsukawa Y, Funahashi Y, Kato M, Hattori R, Gotoh M.
  • Journal Title: Urology Volume: 76
  • Peer Reviewed
• [Presentation] Effect of silodosin on bladder microcirculation in a rat bladder outlet obstruction model : evaluation using a pencil lens charge-coupled device microscopy system (2012)
  • Author(s): Takai S, Yamamoto T, Matsukawa Y, Hattori R, Gotoh M
  • Organizer: 27^<th> Annual Meeting of European Urological Society
  • Place of Presentation: パリ、フランス
  • Year and Date: 2012-02-25
• [Presentation] Effect of tamsulosin on bladder microcirculation in a rat ischemia-reperf usion model, evaluated by pencil lens charge-coupled device microscopy system (2010)
  • Author(s): Mizuno H, Yamamoto T, Aota A, Gotoh M
  • Organizer: 43^<rd> Annual Meeting of American Society of Nephrology
  • Place of Presentation: デンバー、米国
  • Year and Date: 2010-11-20
• [Presentation] Effect of tamsulosin on baldder microcirculation in a rat ischemia-reperfusion model, evaluated by pencil lens charge-coupled device microscopy system. (2010)
  • Author(s): Mizuno H, Yamamoto T, Aota Y, Gotoh M.
  • Organizer: 43^<rd> annual meeting of American Society of Nephrology
  • Place of Presentation: コンベンションセンター、デンバー(コロラド州、米国)
  • Year and Date: 2010-11-20
• [Presentation] 下部尿路閉塞モデルラットにおける塩酸タムスロシンの膀胱微小循環に対する作用の可視化 (2010)
  • Author(s): 水野秀紀、山本徳則、松川宜久、服部良平、後藤百万
  • Organizer: 第17回日本排尿機能学会
  • Place of Presentation: 山梨市
  • Year and Date: 2010-09-30
• [Presentation] 下部尿路閉塞モデルラットにおける塩酸タムスロシンの膀胱微小循環に対する作用の可視化 (2010)
  • Author(s): 水野秀紀、山本徳則、松川宜久、服部良平、後藤百万
  • Organizer: 第17回日本排尿機能学会
  • Place of Presentation: 甲府富士屋ホテル、甲府市(山梨県)
  • Year and Date: 2010-09-30
• [Presentation] Visualization of the effect of tamsulosin hydrochloride on bladder microcirculation in a rat bladder outlet obstruction model, evaluated by pencil lens charge-coupled device microscopy system (2010)
  • Author(s): Mizuno H, Yamamoto T, Aota A, Gotoh M
  • Organizer: 27^<th> Japan-korea Urological Congress
  • Place of Presentation: 京都市
  • Year and Date: 2010-09-11
• [Presentation] Visualization of the effect of tamsulosin hydrochloride on bladder microcirculation in a rat bladder outlet obstruction model, evaluated by pencil lens charge-coupled device microscopy system. (2010)
  • Author(s): Mizuno H, Yamamoto T, Aota Y, Gotoh M.
  • Organizer: 27^<th> Japan-Korea Urological Congress
  • Place of Presentation: 京都国際会議場、京都市(京都府)
  • Year and Date: 2010-09-11
• [Presentation] 下部尿路閉塞と膀胱血流障害:α1ブロッカーによる症状改善メカニズムを探る (2010)
  • Author(s): 後藤百万
  • Organizer: 第98回日本泌尿器科学会総
  • Place of Presentation: 盛岡市
  • Year and Date: 2010-04-29
• [Presentation] 下部尿路閉塞と膀胱血流障害:α1ブロッカーによる症状改善メカニズムを探る (2010)
  • Author(s): 後藤百万
  • Organizer: 第98回日本泌尿器科学会総会
  • Place of Presentation: 盛岡市
  • Year and Date: 2010-04-29