| Project/Area Number |
21592079
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Chiba University |
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Principal Investigator |
ITO Chizuru 千葉大学, 大学院・医学研究院, 講師 (80347054)
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| Co-Investigator(Kenkyū-buntansha) |
TOSHIMORI Kiyotaka 千葉大学, 大学院・医学研究院, 教授 (20094097)
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| Co-Investigator(Renkei-kenkyūsha) |
TOYAM Yoshiro 千葉大学, 大学院・医学研究院, 特任講師 (70009637)
MAEKAWA Mamiko 千葉大学, 大学院・医学研究院, 助教 (20181571)
YAMATOYA Kenji 千葉大学, 大学院・医学研究院, 特任研究員 (80447309)
KAMIMURA Kyoko 千葉大学, 大学院・医学研究院, 技術専門職員 (20422264)
MUTOU Tooru 千葉大学, 大学院・医学研究院, 技術専門職員 (30422265)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | アンドロロジー / 不妊症 / 精子中心体 / 精子機能 |
|---|
| Research Abstract |
ODF2 is a widespread centrosome scaffold component including sperm centrosome. In order to analyze the function of sperm ODF2, we established ODF2 knockout hetero mice and ODF2-EGFP transgenic (TG) mice. ODF2 hetero male mice were infertile due to the functional failure of sperm. We analyzed the association of ODF2 with other centrosome-associated proteins in mature sperm and developing germ cells using ODF2 KO mice and TG mice.
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