| Project/Area Number |
21592094
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
|
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| Research Institution | Kyoto University |
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Principal Investigator |
YURA Shigeo 京都大学, 医学研究科, 非常勤講師 (60335289)
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|---|
| Co-Investigator(Renkei-kenkyūsha) |
SAGAWA Norimasa 三重大学, 医学系研究科, 教授 (00162321)
TATSUMI Keiji 京都大学, 医学研究科, 講師 (10324633)
FUKUHARA Ken 京都大学, 医学研究科, 講師 (00362533)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 産科学 / 妊娠 / 胎児発育障害 / 酸化ストレス / チオレドキシン / 分岐鎖アミノ酸 / 低出生体重児 / 胎児 |
|---|
| Research Abstract |
Undernutrition in utero is closely associated with metabolic syndrome in adulthood. In the present study, we revealed that the expression of thioredoxin binding protein-2(TBP-2) in human placenta is regulated during the progression of pregnancy and dependent on oxygen condition, and is associated with physiological and pathological conditions. We also demonstrated that TBP-2 is a critical molecule that mediates glucose homeostasis during maternal undernutrition and that elevated systolic blood pressure of offspring was ameliorated by maternal ingestion of branched-chain amino acid supplemented diet during food restriction.
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