Investigation for mechanisms of the metabolic syndrome due to intrauterine undernutrition and its prevention
Project/Area Number |
21592094
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Obstetrics and gynecology
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Research Institution | Kyoto University |
Principal Investigator |
YURA Shigeo 京都大学, 医学研究科, 非常勤講師 (60335289)
|
Co-Investigator(Renkei-kenkyūsha) |
SAGAWA Norimasa 三重大学, 医学系研究科, 教授 (00162321)
TATSUMI Keiji 京都大学, 医学研究科, 講師 (10324633)
FUKUHARA Ken 京都大学, 医学研究科, 講師 (00362533)
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Project Period (FY) |
2009 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 産科学 / 妊娠 / 胎児発育障害 / 酸化ストレス / チオレドキシン / 分岐鎖アミノ酸 / 低出生体重児 / 胎児 |
Research Abstract |
Undernutrition in utero is closely associated with metabolic syndrome in adulthood. In the present study, we revealed that the expression of thioredoxin binding protein-2(TBP-2) in human placenta is regulated during the progression of pregnancy and dependent on oxygen condition, and is associated with physiological and pathological conditions. We also demonstrated that TBP-2 is a critical molecule that mediates glucose homeostasis during maternal undernutrition and that elevated systolic blood pressure of offspring was ameliorated by maternal ingestion of branched-chain amino acid supplemented diet during food restriction.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Branched-chain amino acid supplemented diet during maternal food restriction prevents developmental hypertension in adult rat offspring2011
Author(s)
Fuji T, Yura S, Tatsumi K, Mogami H, Fujita K, Kondoh E, Kakui K, Aoe S, Itoh H, Sagawa N, Fujii S, Konishi I
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Journal Title
Journal of Developmental Origins of Health and Disease
Volume: 2
Issue: 03
Pages: 176-183
DOI
Related Report
Peer Reviewed
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