Elucidation of the molecular basis on mammalian gametogenesis by genetic engineering and cell biological techniques
| Project/Area Number |
21592111
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Juntendo University |
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Principal Investigator |
ARAKI Yoshihiko 順天堂大学, 大学院・医学研究科, 先任准教授 (70250933)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 生殖細胞 / TEX101 / Ly6k / dipeptidase 3 / GPIアンカー型タンパク質 / 精子形成 / マウス / 精巣 |
|---|
| Research Abstract |
TEX101, a unique GPI-anchored germ cell marker protein, belongs Ly6-like protein superfamily. In this study, we analyzed molecular characteristics of Ly6k and dipeptidase 3, associated molecules with TEX101 in the mouse testis. The experimental results have shown that precise molecular expression of Ly6k during testicular development, and dipeptidase 3 forms complexes with TEX101 on the surfaces of spermatocytes, spermatids, and testicular spermatozoa.
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Report
(4 results)
Research Products
(38 results)
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[Journal Article] Quantitative peptidomic analysis by a newly developed one-step direct transfer technology without depletion of major blood proteins : Its potential utility for monitoring of pathophysiological status in pregnancy-induced hypertension2011
Author(s)
Araki Y, Nonaka D, Tajima A, Maruyama M, Nitto T, Ishikawa H, Yoshitake H, Yoshida E, Kuronaka N, Asada K, Yanagida M, Nojima M, Yoshida K, Takamori K, Hashiguchi T, Maruyama I, Lee L-J, Tanaka K
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Journal Title
Proteomics
Volume: 11
Pages: 2727-2737
Related Report
Peer Reviewed
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[Journal Article] Equatorin : identification and characterization of the epitope of the MN9 antibody in the mouse2009
Author(s)
Yamatoya K, Yoshida K, Ito C, Maekawa M, Yanagida M, Takamori K, Ogawa H, Araki Y, Miyado K, Toyama Y, Toshimori K.
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Journal Title
Biol. Reprod
Volume: 81
Pages: 889-897
Related Report
Peer Reviewed
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