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Analysis of immunosuppressive microenvironment associated with Epithelial-Mesenchymal Transition in uterine cancer.

Research Project

Project/Area Number 21592144
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionKeio University

Principal Investigator

FUJITA Tomonobu  慶應義塾大学, 医学部, 助教 (20199334)

Co-Investigator(Kenkyū-buntansha) KAWAKAMI Yutaka  慶應義塾大学, 医学部, 教授 (50161287)
AOKI Daisuke  慶應義塾大学, 医学部, 教授 (30167788)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords癌 / 子宮体癌 / 子宮頚癌 / EMT / 免疫抑制 / 上皮間葉転換
Research Abstract

To analyze immunosuppressive tumor microenvironment associated with EMT, novel cancer-associated genes MYEOV and HOXD9 were investigated. After the transfection of MYEOV siRNA into the endometrial cancer cell lines, migration index and invasion index were both significantly lower than that in the control group. mRNA expression of Snail1, Snail2, ZEB1 was significantly reduced, while fibronectin was significantly increased. Silencing of HOXD9 inhibits cell proliferation in 4 of 4 cervical cancer cells, but there were no EMT related gene that was commonly inhibited nor stimulated in 4 cervical cell lines.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (18 results)

All 2011 2010 2009 Other

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (6 results) Remarks (1 results)

  • [Journal Article] Enhanced Cancer Immunotherapy Usi ng STAT3-Depleted Dendritic cells with High Th1-Inducing Ability and Resistanc e to Cancer Cell-Derived Inhibitory Fact ors2011

    • Author(s)
      Iwata-Kajihara T, Sumimoto H, Kawamu ra N, Ueda R, Takahashi T, Mizuguchi H, Miyagishi M, Takeda K, Kawakami Y
    • Journal Title

      J Immunol

      Volume: 187 Pages: 27-36

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunofluorescen ce-detected infiltration of CD4+FOXP3+regulatory T cells is relevant to the prog nosis of patients with endometrial cancer2011

    • Author(s)
      Yamagami W, Susumu N, Tanaka H, Hir asawa A, Banno K, Suzuki N, Tsuda H, Tsukazaki K, Aoki D
    • Journal Title

      Int J Gynecol Cancer

      Volume: 21 Pages: 1628-34

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The mechanisms of cancer immunoescap e and development of overcoming strateg ies2011

    • Author(s)
      Yaguchi T, Sumimoto H, Kudo-Saito C, Tsukamoto N, Ueda R, Iwata-Kajihara T, Nishio H, Kawamura N, Kawakami Y
    • Journal Title

      Int J Hematol

      Volume: 93 Pages: 119-131

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced Cancer Immunotherapy Using STAT3-Depleted Dendritic cells with High Th1-Inducing Ability and Resistance to Cancer Cell-Derived Inhibitory Factors2011

    • Author(s)
      Iwata-Kajihara T, Sumimoto H, Kawamura N, Ueda R, Takahashi T, Mizuguchi H, Miyagishi M, Takeda K, Kawakami Y
    • Journal Title

      J Immunol

      Volume: 187 Issue: 1 Pages: 27-36

    • DOI

      10.4049/jimmunol.1002067

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunofluorescence-detected infiltration of CD4+FOXP3+ regulatory T cells is relevant to the prognosis of patients with endometrial cancer2011

    • Author(s)
      Yamagami W, Susumu N, Tanaka H, Hirasawa A, Banno K, Suzuki N, Tsuda H, Tsukazaki K, Aoki D
    • Journal Title

      Int J Gynecol Cancer

      Volume: 21 Issue: 9 Pages: 1628-34

    • DOI

      10.1097/igc.0b013e31822c271f

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The mechanisms of cancer immunoescape and development of overcoming strategies.2011

    • Author(s)
      Yaguchi T, Sumimoto H, Kudo-Saito C, Tsukamoto N, Ueda R, Iwata-Kajihara T, Nishio H, Kawamura N, Kawakami Y.
    • Journal Title

      Int J Hematol.

      Volume: 93 Pages: 119-131

    • NAID

      10029533724

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced cancer immunotherapy using STAT3-depleted dendritic cells with high Th1-inducing ability and resistance to cancer cell-derived inhibitory factors2011

    • Author(s)
      Iwata-Kajihara T, Sumimoto H, Kawamura N, Ueda R, Takahashi T, Mizuguchi H, Miyagishi M, Takeda K, Kawakami Y.
    • Journal Title

      J Immunol

      Volume: 186(in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RNA Helicase Encoded by Melanoma Differentiation-Associated Gene 5 Is a Major Autoantigen in Patients With Clinically Amyopathic Dermatomyositis Arthritis Rheum2009

    • Author(s)
      Sato S, Hoshino K, Satoh T, Fujita T, Kawakami Y, Fujita T, Kuwana M
    • Volume
      60
    • Pages
      2372-2381
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epithelial Mesenchymal Transition in Human Ocular Chronic Graft-Versus-Host Disease2009

    • Author(s)
      Ogawa Y, Shimmura S, Kawakita T, Yoshida S, Kawakami Y, Tsubota K
    • Journal Title

      Am J Pathol

      Volume: 175 Pages: 2372-81

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] RNA Helicase Encoded by Melanoma Differentiation-Associated Gene 5 Is a Major Autoantigen in Patients With Clinically Amyopathic Dermatomyositis2009

    • Author(s)
      Sato S, Hoshino K, Satoh T, Fujita T, Kawakami Y, Fujita T, Kuwana M.
    • Journal Title

      Arthritis Rheum 60

      Pages: 2193-2200

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epithelial Mesenchymal Transition in Human Ocular Chronis Graft-Versus-Host Disease.2009

    • Author(s)
      Ogawa Y, Shimmura S, Kawakita T, Yoshida S, Kawakami Y, Tsubota K.
    • Journal Title

      Am J Pathol. 175

      Pages: 2372-2381

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] ヒト卵巣癌におけるNF-κBの活性化は免疫抑制状態を誘導する2011

    • Author(s)
      西尾浩、谷口智憲、住本秀敏、梅澤一夫、藤田知信、岩田卓、藤井多久磨、青木大輔、河上裕
    • Organizer
      第70回日本癌学会総会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2011-10-05
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] NF-kB阻害剤の投与はヒト卵巣癌による免疫抑制病態を改善し、腫瘍の免疫学的排除効果を増強する2011

    • Author(s)
      西尾浩、谷口智憲、藤田知信、杉山重里、岩田卓、守井賢二、青木大輔、河上裕
    • Organizer
      第15回日本がん免疫学会総会
    • Place of Presentation
      千里ライフサイエンスセンター(大阪府)
    • Year and Date
      2011-06-30
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Blockade of activated NF-kB in cancer and immune cells may eliminate immunosuppressive state in human ovarian cancer2010

    • Author(s)
      Nishio H, Yaguchi T, Fujita T, Umezawa K, Iwata T, Fujii T, Sumimoto H, Aoki D, Kawakami Y
    • Organizer
      第69回日本癌学会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2010-09-24
    • Related Report
      2011 Final Research Report
  • [Presentation] Blockade of activated NF-kB in cancer and immune cells may eliminate immunosuppressive state in human ovarian cancer2010

    • Author(s)
      Nishio H, Yaguchi T, Fujita T, Umezawa K, Iwata T, Fujii T, Sumimoto H, Aoki D, Kawakami Y
    • Organizer
      第69回日本癌学会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 卵巣癌細胞株におけるPDL1の発現とErk1/2カスケードとの関連2009

    • Author(s)
      岩田卓、藤田知信、守井賢二、宮崎潤一郎、西尾浩、谷口智憲、藤井琢磨、青木大輔、河上裕
    • Organizer
      第39回日本免疫学会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2009-12-04
    • Related Report
      2011 Final Research Report
  • [Presentation] 卵巣癌細胞株におけるPDL1の発現とErk1/2カスケードとの関連2009

    • Author(s)
      岩田卓, 藤田知信, 守井賢二, 宮崎潤一郎, 西尾浩, 谷口智憲, 藤井琢磨, 青木大輔, 河上裕
    • Organizer
      日本免疫学会
    • Place of Presentation
      大阪
    • Year and Date
      2009-12-04
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://web.sc.itc.keio.ac.jp/admedres/index-jp.html

    • Related Report
      2011 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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