Mechanisms of hearing loss caused by gene mutations encoding component proteins of tectorail membrane.
| Project/Area Number |
21592153
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 内耳 / 遺伝子 / 感音難聴 / 細胞外マトリックス |
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| Research Abstract |
One of the causes of sensory neural hearing loss is affected with genetic mutations of encoding proteins of inner ear cochlear components. In this study, we examined the prevalence of genetic mutations and confirmed genotype phenotype correlation in congenital hearing loss patients. In our results, the mutation of TECTA gene encoding tectorial membrane protein may be a high incidence in autosomal dominant hearing loss. Mutation screening can diagnose the genetic cause of hearing loss with tectorial membrane defect.
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Report
(4 results)
Research Products
(5 results)
