2011 Fiscal Year Final Research Report
Mechanisms of hearing loss caused by gene mutations encoding component proteins of tectorail membrane.
| Project/Area Number |
21592153
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 内耳 / 遺伝子 / 感音難聴 / 細胞外マトリックス |
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| Research Abstract |
One of the causes of sensory neural hearing loss is affected with genetic mutations of encoding proteins of inner ear cochlear components. In this study, we examined the prevalence of genetic mutations and confirmed genotype phenotype correlation in congenital hearing loss patients. In our results, the mutation of TECTA gene encoding tectorial membrane protein may be a high incidence in autosomal dominant hearing loss. Mutation screening can diagnose the genetic cause of hearing loss with tectorial membrane defect.
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