Protection against respiratory infection during neonate to infant periods by maternal intranasal immunization
| Project/Area Number |
21592164
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
HOTOMI Muneki 和歌山県立医科大学, 医学部, 講師 (90336892)
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| Co-Investigator(Kenkyū-buntansha) |
YAMANAKA Noboru 和歌山県立医科大学, 医学部, 教授 (10136963)
TAMURA Shinji 和歌山県立医科大学, 医学部, 講師 (10244724)
TOGAWA Akihisa 和歌山県立医科大学, 医学部, 講師 (70305762)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 耳科学 / 肺炎球菌 / 母体免疫 / PspA / Interleukin-17A |
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| Research Abstract |
Pneumococcal vaccine plays an important role in protection against pneumococcal infections. However, infants exhibit impaired innate and adaptive immune responses, which result in insufficient induction of anti-pneumococcal antibody. The current study demonstrated the highly induction of anti-pneumococcal specific antibody among offspring delivered from mother mice immunized with pneumococcal surface protein A. This result would conduce a novel strategy of the development of pneumococcal vaccine.
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Report
(4 results)
Research Products
(23 results)
