A study of a novel allergic rhinitis treatment using nerve repulsion factor semaphorin 3A(Sema3A)
| Project/Area Number |
21592179
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kyorin University (2011)
Juntendo University (2009-2010) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOSHITAKE Hiroshi 順天堂大学, 医学部, 助教 (00396574)
高森 建二 順天堂大学, 医学部, 特任教授 (40053144)
池田 勝久 順天堂大学, 医学部, 教授 (70159614)
冨永 光俊 順天堂大学, 大学院・医学研究科, 研究員 (50468592)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 神経反発因子 / セマフォリ3A / アレルギー性鼻炎 / 鼻粘膜過敏症 / 鼻アレルギー / 神経反発因子Sema3A / Semaphorin 3A / neuropilin-1 / VEGFR-1,2 |
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| Research Abstract |
Semaphorin 3A(Sema3A), a nerve repulsion factor, has been reported to be specifically associated with a role in chronic inflammation of the nerves(i. e., in cases of nasal mucosal hypersensitivity), but not in allergic inflammation in the human nasal mucosa.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] Antimicrobial peptides human beta-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine IL-31 by human mast cells2010
Author(s)
Niyonsaba F, Ushio H, Hara M, Yokoi H, Tominaga M, Takamori K, Kajiwara N, Saito H, Nagaoka I, Ogawa H, Okumura K
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Journal Title
J Immunol
Volume: 184
Pages: 3526-34
Related Report
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[Journal Article] Antimicrobial peptides human beta-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine IL-31 by human mast cells.2010
Author(s)
Niyonsaba F, Ushio H, Hara M, Yokoi H, Tominaga M, Takamori K, Kajiwara N, Saito H, Nagaoka I, Ogawa H, Okumura K
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Journal Title
J Immunol.
Volume: 184
Pages: 3526-3534
Related Report
Peer Reviewed
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[Journal Article] Bacterial contamination of Multiple-use atomizers commonly used in Japan2009
Author(s)
Ikeda K, Sakai Y, Haruyama T, Misawa N, Misawa N, Hori S, Kusunoki T, Furukawa M, Yokoi H, Yokoi N, Ichihari Y, Kawano K, Matsumoto F, Hayashi C, Narui Y, Iizuka T, Ito S, Inoshita A, Kasai M, Saito T, Minekawa A, Oba S, Cho Y
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Journal Title
Indian J Otolaryngol Head Neck Surg.
Volume: 61
Pages: 193-6
Related Report
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