| Project/Area Number |
21592234
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
|
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| Research Institution | Nagasaki University |
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Principal Investigator |
SUZUMA Kiyoshi 長崎大学, 大学院・医歯薬学総合研究科, 准教授 (80335265)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KITAOKA Takashi 長崎大学, 大学院・医歯薬学総合研究科, 教授 (80234235)
FUJIKAWA Azusa 長崎大学, 病院, 講師 (60363503)
TUIKI Eiko 長崎大学, 大学院・医歯薬学総合研究科, 助教 (30363493)
MATSUMOTO Makiko 長崎大学, 病院, 助教 (70437903)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
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| Keywords | 糖尿病網膜症 / VEGF / エリスロポエチン / コハク酸 / 機械的伸展 / mechanical stress |
|---|
| Research Abstract |
In proliferative diabetic retinopathy, levels of succinate increased significantly. However, in proliferative diabetic retinopathy after anti-VEGF therapy, levels of succinate decreased significantly. Since it has been previously reported that succinate induces VEGF expression, a positive feedback mechanism from VEGF to succinate was suggested. These data were novel findings.
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