Involvement of Aquaporin in neovascularization of ocular diseases
| Project/Area Number |
21592235
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Nagasaki University |
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Principal Investigator |
KITAOKA Takashi 長崎大学, 大学院・医歯薬学総合研究科, 教授 (80234235)
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| Co-Investigator(Kenkyū-buntansha) |
KUMAGAMI Takeshi 長崎大学, 病院, 准教授 (70294329)
SUZUMA Kiyoshi 長崎大学, 大学院・医歯薬学総合研究科, 准教授 (80335265)
FUJIKAWA Azusa 長崎大学, 病院, 講師 (60363503)
TUIKI Eiko 長崎大学, 大学院・医歯薬学総合研究科, 助教 (30363493)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | アクアポリン / 血管内皮増殖因子 / 網膜色素上皮 / 硝子体注射 / 網膜 / レーザー光凝固 / 走査レーザー検眼鏡 / 光干渉断層計 / 光干渉断層系 / 水チャンネル / 新生血管 / 色素上皮 / 硝子体内注射 / 網膜浮腫 / 加齢黄斑変性 / 走査型レーザー検眼鏡 |
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| Research Abstract |
It was reported that water-channel Aquaporin(AQP) was not only related to water transportation but also induced neovascularization(Saadoun S et al. Nature 2005, 434 : 786). In this study, we examined that AQP1 in retinal pigment epithelium and AQP4 in retinal Muller cells may relate to neovascularization in age-related macular degeneration. It was suggested that AQP1 may relate to age-related macular degeneration and optical coherence tomography and scanning laser ophthalmoscope are useful tools for studying the influence of neovascularization in clinical examination
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Report
(4 results)
Research Products
(10 results)
