Application to the clarification and treatment of endoplasmic reticulum stress related the retinal pigment epithelium cells in Age-related macular degeneration.
| Project/Area Number |
21592251
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Kansai Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OGATA Nahoko 関西医科大学, 医学部, 准教授 (60204062)
ANDO Akira 関西医科大学, 医学部, 講師 (50319612)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 小胞体ストレス / 加齢黄斑変性 / 網膜色素上皮 / Tight junction / 細胞間接着因子 / VEGF / PEDF / 細胞間接着分子 |
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| Research Abstract |
The endoplasmic reticulum(ER) is an important intracellular organelle responsible for the biosynthesis and folding of proteins. It has been reported that ER stress has been linked to the diabetic retinopathy and age-related macular degeneration(AMD). Increased protein expressions and transepithelial electrical resistance of tight junctions by ER stress in RPE cells indicate that ER stress can alter the function of RPE cells and may be involved in the pathogenesis of AMD.
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Report
(4 results)
Research Products
(103 results)
