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A novel glaucoma treatment drug research through caspase siRNA.

Research Project

Project/Area Number 21592260
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionSaga University

Principal Investigator

OKINAMI Satoshi  佐賀大学, 医学部, 教授 (70089100)

Co-Investigator(Kenkyū-buntansha) HIRATA Akira  佐賀大学, 医学部, 准教授 (60295144)
ISHIKAWA Shinichiro  佐賀大学, 医学部, 助教 (00404129)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords遺伝子 / 細胞・組織 / 蛋白質 / 神経保護 / アポトーシス / 網膜視神経節細胞 / 緑内障 / 組織・細胞
Research Abstract

Intra-vitreous injection of atelocollagen and caspase-3 siRNA complex may protect the retinal ganglion cell damage induced by transient ischemic injury(a glaucoma animal model).

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report

Research Products

(8 results)

All 2011 2010 2009

All Presentation (8 results)

  • [Presentation] アテロコラーゲンとcaspase3に対するsiRNAの混合物による神経保護効果の検討2011

    • Author(s)
      石川慎一郎
    • Organizer
      第115回日本眼科学会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] Neuroprotective effects of siRNA, targeted caspase-3, and atelocollagen complex on rat retinal damage induced by transient ischemic injury2011

    • Author(s)
      石川慎一郎
    • Organizer
      ARVO
    • Place of Presentation
      米国フロリダ
    • Year and Date
      2011-05-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] アテロコラーゲンとcaspase3に対するsiRNAの混合物による神経保護効果の検討2011

    • Author(s)
      石川慎一郎、平田憲、沖波聡
    • Organizer
      日本眼科学会
    • Related Report
      2011 Final Research Report
  • [Presentation] Neuroprotectibe effects of siRNA, targeted caspase-3, and atellocollagen complex on rat retinal damage induced by transient ischemic injury2011

    • Author(s)
      Shinichiro Ishikawa, Ken Hirata, Satoshi Okinami
    • Organizer
      ARVO
    • Related Report
      2011 Final Research Report
  • [Presentation] アテロコラーゲンによる網膜毒性の検討2010

    • Author(s)
      石川慎一郎
    • Organizer
      2010年日本眼科学会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-04-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] アテロコラーゲンによる網膜毒性の検討2010

    • Author(s)
      石川慎一郎、平田憲、沖波聡
    • Organizer
      日本眼科学会
    • Related Report
      2011 Final Research Report
  • [Presentation] 網膜虚血再灌流モデルラットにおけるDiabloに対するsiRNAによる神経保護効果の検討2009

    • Author(s)
      石川慎一郎
    • Organizer
      日本緑内障学会
    • Place of Presentation
      沖縄
    • Year and Date
      2009-11-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] 網膜虚血再灌流モデルラットにおけるDiabloに対するsiRNAによる神経保護効果の検討2009

    • Author(s)
      石川慎一郎、平田憲、沖波聡
    • Organizer
      日本緑内障学会
    • Related Report
      2011 Final Research Report

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Published: 2009-03-31   Modified: 2016-04-21  

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