| Project/Area Number |
21592273
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatric surgery
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| Research Institution | Chiba University |
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Principal Investigator |
SAITO Takeshi 千葉大学, 医学部・附属病院, 講師 (20406044)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIDA Hideo 千葉大学, 大学院・医学研究院, 教授 (60210712)
HISHIKI Tomoro 千葉大学, 大学院・医学研究院, 講師 (00375776)
MITUNAGA Tetsuya 千葉大学, 医学部附属病院, 助教 (80375774)
NAKATA Mituyuki 千葉大学, 医学部附属病院, 助教 (90375775)
SATO Yoshiharu 千葉大学, 医学部附属病院, 助教 (60375772)
TERUI Keita 千葉大学, 医学部附属病院, 助教 (70375773)
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|---|
| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 先天性消化器疾患学 / 胆道閉鎖症 / サイトカイン / サイトカインネットワーク / 自然免疫 / フローサイトメトリー |
|---|
| Research Abstract |
Using the serum and liver specimens taken from biliary atresia (BA)patients around the operation, we investigated both the systemic and local immunological environment of BA. It was suggested the significant difference between Th1 and Th2 cytokines expression levels has not been found in the systemic immunity. However, the representative local environment in the liver showed Th1 polarization.
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