Study of evolution of osteoclasts regulating factors in teleost fish
Project/Area Number |
21592319
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Morphological basic dentistry
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Research Institution | Hokkaido University |
Principal Investigator |
DOMON Takanori 北海道大学, 大学院・歯学研究科, 教授 (50217618)
|
Co-Investigator(Kenkyū-buntansha) |
YOSHIMURA Yoshitaka 北海道大学, 大学院・歯学研究科, 助教 (30230816)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | 口腔解剖学(含組織学・発生学) / 破骨細胞 / 硬骨魚類 / メダカ / 分離培養 / 走査型電子顕微鏡 / 透過型電子顕微鏡 / TRAP陽性 / TRAP陽性細胞 / 咽頭歯 / 咽頭歯骨 |
Research Abstract |
The origin of osteoclasts resorbing bone remains unknown. Bone tissue is seen on teleost fish in phylogeny, and there old osteoclasts would be seen. The present study established the culture system of isolated Japanese medaka and observed their structure by light-and electron microscopy. The cultured cells showed no resorptive lacuna but etched surfaces on sperm whale dentine. These results may be related to the evolution of regulating fac tors of osteoclasts.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Platinum Nanoparticles Suppress Osteoclastogenesis Through Scavenging of Reactive Oxygen Species Produced in RAW264.7 Cells2011
Author(s)
Nomura M, Yoshimura Y, Kikuiri T, Hasegawa T, Taniguchi Y, Deyama Y, Koshiro K, Sano H, Suzuki K, Inoue N.
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Journal Title
Journal of Pharmacological Sciences
Volume: 117
Issue: 4
Pages: 243-252
DOI
NAID
ISSN
1347-8613, 1347-8648
Related Report
Peer Reviewed
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