| Project/Area Number |
21592336
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
BABA Tomomi 長崎大学, 大学院・医歯薬学総合研究科, 助教 (60189727)
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| Co-Investigator(Renkei-kenkyūsha) |
KOMORI Toshihisa 長崎大学, 大学院・医歯薬学総合研究科, 教授 (00252677)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | Runx2 / 歯 / 第三象牙質 / 象牙芽細胞 / 分化 / 組織 / 組織化学 / 組織・細胞 / 組織細胞化学 / 硬組織基質タンパク質 / トランスジェニックマウス / オステオポンチン / オステオカルシン |
|---|
| Research Abstract |
The aim of this study is to clarify the role of Runx2, which is an essential transcription factor for osteoblast differentiation, in tertiary dentin formation. We examined tertiary dentin of human teeth, and reparative dentin that was experimentally formed in mouse molars, and have immunohistochemically demonstrated that Runx2 was expressed in the formative cells of tertiary dentin, and osteopontin and osteocalcin, which were highly present in bone tissue, were also expressed in tertiary dentin. Thus, it was suggested that Runx2 plays a role in tertiary dentin formation.
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