| Project/Area Number |
21592340
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Iwate Medical University |
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Principal Investigator |
|
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| Co-Investigator(Kenkyū-buntansha) |
NEMOTO Yuko (NEMOTO OHARA Yuko) 長崎大学, 大学院・医歯薬学総合研究科, 准教授 (10164667)
|
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| Co-Investigator(Renkei-kenkyūsha) |
SASAKI Minoru 岩手医科大学, 歯学部, 准教授 (40187133)
SHIMOYAMA Yu 岩手医科大学, 歯学部, 助教 (90453331)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
|
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| Keywords | SLPI / 歯肉上皮細胞 / P. gingivalis / 感染抑制 / P.gingivalis |
|---|
| Research Abstract |
The results indicated that gingival epithelial cells could be a substantial producer of secretory leukocyte protease inhibitor(SLPI) that functions inhibitory to the pathogenic Porphyromonas gingivalis protease in gingival crevices. It was also suggested that the SLPI production could increase in response to P. gingivalis through the stimulation with its pathogenic constituents.
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