Analysis of vascular endothelial cell differentiation and growth system in the rat tongue inflammation model.

• Project/Area Number: 21592348
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Morphological basic dentistry
• Research Institution: Tsurumi University
• Principal Investigator: KURODA Noriyuki 鶴見大学, 歯学部, 助教 (50359915)
• Co-Investigator(Kenkyū-buntansha): SATO Etsuji 鶴見大学, 歯学部, 教授 (10162447)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 口腔解剖学(含組織学・発生学) / 舌炎 / LPS / アデノシンレセプター / 抗原提示細胞

Research Abstract

To make the model of tongue inflammation, inject the LPS with incomplete Freund's adjuvant. About 8days after the injection, the luminal areas of blood vessels were increased. But inject antagonists of adenosine receptors before to inject the LPS and incomplete Freund's adjuvant, the ratio of blood vessels in the lingual tissue was remarkably reduced. These results show that adenosine receptors are very important roll of vascular endothelial growth.

Research Products

• [Journal Article] Immunocompetent cells and cytokine expression in the rat periodontal ligament at the initial stage of orthodontic tooth movement (2011)
  • Author(s): Shunsuke Baba, Noriyuki Kuroda, Chihiro Arai, Yoshiki Nakamura, Tetsuji Sato
  • Journal Title: Archives of Oral Biology Volume: 56 Pages: 466-473
  • Peer Reviewed
• [Journal Article] Up-regulation of vascular endothelial growth factor expression by adenosine through adenosine A2 receptors in the rat tongue treated with endotoxin (2009)
  • Author(s): Yaiko Hara, Noriyuki Kuroda, Kouji Inoue, Tetsuji Sato
  • Journal Title: Archives of Oral Biology Volume: 54 Pages: 932-942
  • Peer Reviewed
• [Journal Article] Up-regulation of vascular endothelial growth factor expression by adenosine through adenosine A2 receptors in the rat tongue treated with endotoxin (2009)
  • Author(s): Yaiko Hara, et al.
  • Journal Title: Archives of Oral Biology 54 Pages: 932-942
  • Peer Reviewed
• [Presentation] 舌炎モデルを用いた脈管形成機構の解析 (2010)
  • Author(s): 原矢委子
  • Organizer: 第115回日本解剖学会総会・全国学術集会
  • Place of Presentation: 盛岡
• [Presentation] Angiogenesis by VEGF released from antigen-presenting cells during the course of LPS-induced glossitis of rats (2009)
  • Author(s): Hara Y, Kuroda N, Sato T
  • Organizer: 11th International Workshop on Langerhans Cells
  • Place of Presentation: Funchal/Madeira/Portugal
• [Presentation] An endogenous signal for dendritic cell maturation evaluated in the inflammatory lingual tissue of rats (2009)
  • Author(s): 原矢委子、黒田範行、佐藤哲二
  • Organizer: 第19回日本樹状細胞研究会
  • Place of Presentation: 淡路夢舞台国際会議場
• [Presentation] Angiogenesis by VEGF released from antigen-presenting cells during the course of LPS-induced glossitis of rats. (2009)
  • Author(s): Hara Yaiko, et al.
  • Organizer: 11th International Workshop on Langerhans Cells
  • Place of Presentation: Funchal/Madeira/Portugal