| Project/Area Number |
21592357
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
|
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| Research Institution | Osaka University |
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Principal Investigator |
WADA Koichiro 大阪大学, 大学院・歯学研究科, 准教授 (90263467)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KAMISAKI Yoshinori 大阪大学, 大学院・歯学研究科, 教授 (40116017)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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|---|
| Keywords | 核内受容体 / Mcl-1 / 扁平上皮癌 / アノイキス / 浸潤 / PPAR / 増殖 / 転移 / 癌治療 / 生活習慣病 / 癌細胞 / Aquaporin |
|---|
| Research Abstract |
Myeloid cell leukemia-1(Mcl-1), a member of the B-cell lymphoma-2(Bcl-2) family, has been reported to be a critical survival factor in hematopoietic cells, yet little data exists for a role of Mcl-1 in human squamous cell carcinoma(SCC). A high level expression of Mcl-1 was observed in tumor cells of human primary SCC, lymph node metastasis tissues, and SCC cell lines. We observed that Mcl-1 siRNA inhibited the growth of SCCs accompanied with apoptosis. We also observed the involvement of aquaporin 3 on the growth of SCCs. These results imply a potentially important and novel role of the inhibition of Mcl-1 or aquaporin 3 by the use of specific siRNA in the treatment of SCC.
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