Role of Mcl-1 expression on tumor cell growth and metastasis
| Project/Area Number |
21592357
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
WADA Koichiro 大阪大学, 大学院・歯学研究科, 准教授 (90263467)
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| Co-Investigator(Kenkyū-buntansha) |
KAMISAKI Yoshinori 大阪大学, 大学院・歯学研究科, 教授 (40116017)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 核内受容体 / Mcl-1 / 扁平上皮癌 / アノイキス / 浸潤 / PPAR / 増殖 / 転移 / 癌治療 / 生活習慣病 / 癌細胞 / Aquaporin |
|---|
| Research Abstract |
Myeloid cell leukemia-1(Mcl-1), a member of the B-cell lymphoma-2(Bcl-2) family, has been reported to be a critical survival factor in hematopoietic cells, yet little data exists for a role of Mcl-1 in human squamous cell carcinoma(SCC). A high level expression of Mcl-1 was observed in tumor cells of human primary SCC, lymph node metastasis tissues, and SCC cell lines. We observed that Mcl-1 siRNA inhibited the growth of SCCs accompanied with apoptosis. We also observed the involvement of aquaporin 3 on the growth of SCCs. These results imply a potentially important and novel role of the inhibition of Mcl-1 or aquaporin 3 by the use of specific siRNA in the treatment of SCC.
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Report
(4 results)
Research Products
(63 results)
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[Journal Article] Infection of specific strains of Streptococcus mutans, oral bacteria, confers a risk of ulcerative colitis2012
Author(s)
Kojima A, Nakano K, Wada K, Takahashi H, Katayama K, Yoneda M, Higurashi T, Nomura R, Hokamura K, Muranaka Y, Matsuhashi N, Umemura K, Kamisaki Y, Nakajima A, Ooshima T.
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Journal Title
Scientific Reports
Volume: 2
Issue: 1
Pages: 332-332
DOI
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[Journal Article] Involvement of a periodontal pathogen, Porphyromonas gingivalis on the pathogenesis of non-alcoholic fatty liver disease2012
Author(s)
Yoneda M, Naka S, Nakano K, Wada K, Endo H, Mawatari H, Imajo K, Nomura R, Hokamura K, Ono M, Murata S, Tohnai I, Sumida Y, Shima T, Kuboniwa M, Umemura K, Kamisaki Y, AmanoA, OkanoueT, OoshimaT, Nakajima A.
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Journal Title
BMC Gastroenterology
Volume: 12
Pages: 16-16
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[Journal Article] The collagen-binding protein of Streptococcus mutans is involved in hemorrhagic stroke2011
Author(s)
Nakano K, Hokamura K, Taniguchi N, Wada K, Kudo C, Nomura R, Kojima A, Naka S, Muranaka Y, Thura M, Nakajima A, Masuda K, Nakagawa I, Speziale P, Shimada N, Amano A, Kamisaki Y, Tanaka T, Umemura K, Ooshima T.
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Journal Title
Nature Communications
Volume: 2
Issue: 1
Pages: 485-485
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[Journal Article] Leptin receptor is involved in STAT3 activation in human colorectal adenoma2011
Author(s)
Uchiyama T, Takahashi H, Sugiyama M, Sakai E, Hosono K, Endo H, Yoneda K, Yoneda M, Inamori M, Nagashima Y, Inayama Y, Wada K, Nakajima A.
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Journal Title
Cancer Science
Volume: 102
Pages: 367-372
NAID
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[Journal Article] Characterization of aortic aneurysms in cardiovascular disease patients harboring Porphyromonas gingivalis2011
Author(s)
Nakano K, Wada K, Nomura R, Nemoto H, Inaba H, Kojima A, Naka S, Hokamura K, MukaiT, Nakajima A, Umemura K, Kamisaki Y, YoshiokaH, Taniguchi K, Amano A, Ooshima T.
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Journal Title
Oral Disease
Volume: 17
Pages: 370-378
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[Journal Article] Liver abscess caused by periodontal bacterial infection with Fusobacterium necrophorum2011
Author(s)
Yoneda M, Kato S, Mawatari H, Kirikoshi H, Imajo K, Fujita K, Endo H, Takahashi H, Inamori M, Kobayashi N, Kubota K, Saito S, Tohnai I, Watanuki K, Wada K, Maeda S, Nakajima A.
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Journal Title
Hepatology Research
Volume: 41
Pages: 194-196
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[Journal Article] Leptin acts as a growth factor for colorectal tumours at stages subsequent to tumour initiation in murine colon carcinogenesis2011
Author(s)
Endo H, Hosono K, Uchiyama T, Sakai E, Sugiyama M, Takahashi H, Nakajima N, Wada K, Takeda K, Nakagama H, Nakajima A.
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Journal Title
Gut
Volume: 60
Pages: 1363-1371
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[Journal Article] Role of the long form leptin receptor and of the STAT3 signaling pathway in colorectal cancer progression2011
Author(s)
Uchiyama T, Takahashi H, Endo H, Sugiyama M, Sakai E, Hosono K, Nagashima Y, Inayama Y, Wada K, Hippo Y, Nakajima A.
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Journal Title
International Journal of Oncology
Volume: 39
Pages: 935-940
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[Journal Article] cis9, trans11-conjugated linoleic acid differentiates mouse 3T3-L1 preadipocytes into mature small adipocytes through induction of peroxisome proliferator-activated receptor gamma2010
Author(s)
Sakuma S, Nishioka Y, Imanishi R, Nishikawa K, Sakamoto H, Fujisawa J, Wada, K, Kamisaki Y, Fujimoto Y.
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Journal Title
Journal of Clinical Biochemistry and Nutrition
Volume: 47
Pages: 167-173
NAID
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[Journal Article] Involvement of JNK pathway in the promotion of the early stage of colorectal carcinogenesis under high-fat dietary condition2009
Author(s)
Endo H, Hosono K, Fujisawa T, Takahashi H, Sugiyama M, Yoneda K, Nozaki Y, Fujita K, Yoneda M, Inamori M, Wada K, Nakagama H, Nakajima A.
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Journal Title
Gut
Volume: 58
Pages: 1637-16431
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[Journal Article] Influence of iNOS polymorphisms in Japanese patients with nonalcoholic fatty liver disease2009
Author(s)
Yoneda M, Hotta K, Nozaki Y, Endo H, Tomeno W, Watanabe S, Hosono K, Mawatari H, Iida H, Fujita K, Takahashi H, Kirikoshi H, Kobayashi H, Inamori M, Kubota K, Shimamura T, Saito S, Maeyama S, Wada K, Nakajima A.
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Journal Title
Hepatology Research
Volume: 39
Pages: 963-971
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[Journal Article] Association between angiotensin II type1receptor polymorphisms and the occurrence of nonalcoholic fatty liver disease.2009
Author(s)
Yoneda M, Hotta K, Nozaki Y, Endo H, Uchiyama T, Mawatari H, Iida H, Kato S, Fujita K, Takahashi H, Kirikoshi H, Kobayashi N, Inamori M, Abe Y, Kubota K, Saito S, Maeyama S, Wada K, Nakajima A.
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Journal Title
Liver International
Volume: 29
Pages: 1078-1085
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Peer Reviewed
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