Involvement of a novel signaling molecule, PRIP in the regulation of bone metabolism through reproduction system
| Project/Area Number |
21592365
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
MATSUDA Miho 九州大学, 歯学研究院, 助教 (40291520)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 生殖・ホルモン・骨代謝 / 骨代謝 / 骨密度 / PRIP / 破骨細胞 / 骨芽細胞 / ホルモン |
|---|
| Research Abstract |
This study revealed the following :(i) PRIP was involved in female reproductive system, especially in gonadotropins secretion and ovarian follicle maturation.(ii) The bone mineral density and trabecular bone volume were higher in PRIP-gene deficient mice due to enhanced bone formation and decreased bone resorption, indicating that PRIP is implicated in the negative regulation of bone formation.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] Involvement of PRIP, phospholipase C-related, but catalytically inactive protein2011
Author(s)
Tsutsumi, K., Matsuda, M., Kotani, M., Murakami, A., Mizokami, A., Takahashi, I., Terada, Y., Kanematsu, T., Fukami, K., Takenawa, T., Jimi, E. and Hirata, M.
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Journal Title
in bone formation. J. Biol. Chem
Volume: 286
Pages: 31032-31042
Related Report
Peer Reviewed
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[Journal Article] Assay of dense-core vesicle exocytosis using permeabilized PC12 cells2010
Author(s)
Gao, J., Takeuchi, H., Umebayashi, H., Zhang, Z., Matsuda, M. and Hirata, M.
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Journal Title
Adv. Enz. Regul
Volume: 50
Pages: 237-246
Related Report
Peer Reviewed
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[Journal Article] Involvement of phospholipase C-related inactive protein in the mouse reproductive system through the regulation of gonadotropin levels2009
Author(s)
Matsuda, M, Tsutsumi, K., Kanematsu, T., Fukami, K., Terada, Y., Takenawa, T., Nakayama, K. I., Hirata, M.
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Journal Title
Biol Reprod
Volume: 81
Pages: 681-689
Related Report
Peer Reviewed
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